What does the evidence say about Sodium Bicarbonate Endurance Exercise Meta-Analysis?

The current Migaku evidence database contains 2 reusable source documents for Sodium Bicarbonate Endurance Exercise Meta-Analysis. This answer focuses on benefits, uncertainty, and practical interpretation. - Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool, and certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. [Ge X (2026); evidence level 1] - NaHCO3 ingestion increased post-exercise blood lactate (MD = 1.73 mmol/L, 95% CI: 0.97 to 2.49), HCO3- (MD = 2.73 mmol/L, 95% CI: 2.16 to 3.30), and pH (MD = 0.050, 95% CI: 0.025 to 0.075). [Ge X (2026); evidence level 1] - Certainty of evidence was low for HIIE performance and HCO3- and very low for blood lactate and pH. [Ge X (2026); evidence level 1] - Background Sodium bicarbonate (NaHCO3) ingestion can induce extracellular alkalosis, but its effects on high-intensity intermittent exercise (HIIE) performance in team sports remain unclear. [Ge X (2026); evidence level 1] - Purpose We tested the hypotheses that sodium bicarbonate (SB) supplementation improves performance, reduces markers of acute kidney injury (AKI) risk, and increases markers of acute gastrointestinal injury (AGI) during repeated sprints in the heat. [Specht JW (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.