topicSodium Bicarbonate Endurance Exercise Meta-Analysis
claimRisk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool, and certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
evidence level1
citationGe X (2026)
sourceEffects of acute or short-term oral sodium bicarbonate supplementation on high-intensity intermittent exercise performance and physiological responses in team-sport athletes: a systematic review and meta-analysis.
topicSodium Bicarbonate Endurance Exercise Meta-Analysis
claimNaHCO3 ingestion increased post-exercise blood lactate (MD = 1.73 mmol/L, 95% CI: 0.97 to 2.49), HCO3- (MD = 2.73 mmol/L, 95% CI: 2.16 to 3.30), and pH (MD = 0.050, 95% CI: 0.025 to 0.075).
evidence level1
citationGe X (2026)
sourceEffects of acute or short-term oral sodium bicarbonate supplementation on high-intensity intermittent exercise performance and physiological responses in team-sport athletes: a systematic review and meta-analysis.
topicSodium Bicarbonate Endurance Exercise Meta-Analysis
claimCertainty of evidence was low for HIIE performance and HCO3- and very low for blood lactate and pH.
evidence level1
citationGe X (2026)
sourceEffects of acute or short-term oral sodium bicarbonate supplementation on high-intensity intermittent exercise performance and physiological responses in team-sport athletes: a systematic review and meta-analysis.
topicSodium Bicarbonate Endurance Exercise Meta-Analysis
claimBackground Sodium bicarbonate (NaHCO3) ingestion can induce extracellular alkalosis, but its effects on high-intensity intermittent exercise (HIIE) performance in team sports remain unclear.
evidence level1
citationGe X (2026)
sourceEffects of acute or short-term oral sodium bicarbonate supplementation on high-intensity intermittent exercise performance and physiological responses in team-sport athletes: a systematic review and meta-analysis.
topicSodium Bicarbonate Endurance Exercise Meta-Analysis
claimPurpose We tested the hypotheses that sodium bicarbonate (SB) supplementation improves performance, reduces markers of acute kidney injury (AKI) risk, and increases markers of acute gastrointestinal injury (AGI) during repeated sprints in the heat.
evidence level4
citationSpecht JW (2026)
sourceEffect of sodium bicarbonate on performance and markers of kidney and gastrointestinal injury during repeated sprints in the heat.
topicSodium Bicarbonate Endurance Exercise Meta-Analysis
claimUrine and plasma collected pre-ingestion and pre-, post-, and 1-h post-exercise were analyzed for markers of AKI risk, AGI, and endotoxemia.
evidence level4
citationSpecht JW (2026)
sourceEffect of sodium bicarbonate on performance and markers of kidney and gastrointestinal injury during repeated sprints in the heat.
topicSodium Bicarbonate Endurance Exercise Meta-Analysis
claimResults SB increased peak (average difference between conditions: 21 ± 11 W, condition effect: p = 0.02) and average (p = 0.03) power across the sprints.
evidence level4
citationSpecht JW (2026)
sourceEffect of sodium bicarbonate on performance and markers of kidney and gastrointestinal injury during repeated sprints in the heat.
topicSodium Bicarbonate Endurance Exercise Meta-Analysis
claimMethods Using a double-blind design, 10 recreationally endurance-trained participants ingested 0.2 g/kg of body weight of SB or placebo before cycling in the heat (dry-bulb: 40 °C, relative humidity: 20%).
evidence level4
citationSpecht JW (2026)
sourceEffect of sodium bicarbonate on performance and markers of kidney and gastrointestinal injury during repeated sprints in the heat.