skin aging

Is Polypodium Leucotomos Skin Photoprotection Randomized Trial safe?

Updated October 2026

Quick Answer

Polypodium Leucotomos Skin Photoprotection Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: Results : Throughout the intervention, MED gradually increased, while Δ a* decreased in the IP group.

Key Takeaways

  • 01Results : Throughout the intervention, MED gradually increased, while Δ a* decreased in the IP group. [Keršmanc P (2025)]
  • 02Background/Objectives : Oral photoprotection is gaining attention as a complementary approach to conventional sun protection. [Keršmanc P (2025)]
  • 03This randomized double-blind placebo-controlled study evaluated the effects of an 8-week dietary intervention with a syrup supplement containing Polypodium leucotomos extract (PLE), Red Orange Extract (ROE), and vitamins A, C, D, and E on minimal erythema dose (MED), UVB-induced erythema (Δ a* ), and pigmentation changes (ΔMI). [Keršmanc P (2025)]
The current Migaku evidence database contains 1 reusable source document for Polypodium Leucotomos Skin Photoprotection Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Results : Throughout the intervention, MED gradually increased, while Δ a* decreased in the IP group. [Keršmanc P (2025); evidence level 2] - Background/Objectives : Oral photoprotection is gaining attention as a complementary approach to conventional sun protection. [Keršmanc P (2025); evidence level 2] - This randomized double-blind placebo-controlled study evaluated the effects of an 8-week dietary intervention with a syrup supplement containing Polypodium leucotomos extract (PLE), Red Orange Extract (ROE), and vitamins A, C, D, and E on minimal erythema dose (MED), UVB-induced erythema (Δ a* ), and pigmentation changes (ΔMI). [Keršmanc P (2025); evidence level 2] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

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Keep learning from this answer

GuideCollagen Supplements: What They Can and Cannot Do for Skin and JointsLegacy library material — check the original sources.DataPolypodium Leucotomos Skin Photoprotection Randomized Trial Evidence TableLegacy library material — check the original sources.DataVitamin E Skin Photoprotection Randomized Trial Evidence TableLegacy library material — check the original sources.DataTomato Lycopene Skin Photoprotection Randomized Trial Evidence TableLegacy library material — check the original sources.

Sources

  1. Effects of Eight-Week Supplementation Containing Red Orange and <i>Polypodium leucotomos</i> Extracts on UVB-Induced Skin Responses: A Randomized Double-Blind Placebo-Controlled Trial.