Does Multivitamin Cognitive Performance Randomized Trial work?

Updated October 2026

Quick Answer

Multivitamin Cognitive Performance Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: The d emographic shift toward an older population is accelerating the prevalence of age-related diseases.

Key Takeaways

  • 01The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. [Kuerec AH (2026)]
  • 02Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. [Kuerec AH (2026)]
  • 03The multivitamin with guaraná treatment was associated with significantly enhanced Serial Threes performance and self-rated contentment. [Scholey A (2013)]
  • 04fMRI revealed that both multivitamin treatments increased activation in areas associated with working memory and attentional processing, with the effect being greater in the multivitamin with guaraná condition. [Scholey A (2013)]
The current Migaku evidence database contains 2 reusable source documents for Multivitamin Cognitive Performance Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. [Kuerec AH (2026); evidence level 2] - Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. [Kuerec AH (2026); evidence level 2] - The multivitamin with guaraná treatment was associated with significantly enhanced Serial Threes performance and self-rated contentment. [Scholey A (2013); evidence level 4] - fMRI revealed that both multivitamin treatments increased activation in areas associated with working memory and attentional processing, with the effect being greater in the multivitamin with guaraná condition. [Scholey A (2013); evidence level 4] - Furthermore, they demonstrate for the first time increased brain activation from multivitamin preparations both with and without guaraná, as measured using fMRI. [Scholey A (2013); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticals.
  2. Acute effects of different multivitamin mineral preparations with and without Guaraná on mood, cognitive performance and functional brain activation.