Structured evidence table for Citrus Flavonoids Cognitive Performance Randomized Trial, generated from 3 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Citrus Flavonoids Cognitive Performance Randomized Trial | 4 5 4 Flavanones, also known as dihydroflavones, represent a subclass of flavonoids, predominantly found in citrus fruits, including lemons, limes, oranges, grapefruits, mandarins, clementines, tangelos, and grapes [,]. | 3 | Cichon Natalia (2025) | Flavanones as Modulators of Gut Microbiota and Cognitive Function |
| Citrus Flavonoids Cognitive Performance Randomized Trial | In grapefruits, the highest concentration was found for naringin (48–1220 mg/L), whereas in tangelos, neohesperidin was the most abundant (100–400 mg/L) []. | 3 | Cichon Natalia (2025) | Flavanones as Modulators of Gut Microbiota and Cognitive Function |
| Citrus Flavonoids Cognitive Performance Randomized Trial | Naringenin is also found in(honeybush tea), propolis, and the sprouts of certain plants, such asvar.(broccoli) and(lentils). | 3 | Cichon Natalia (2025) | Flavanones as Modulators of Gut Microbiota and Cognitive Function |
| Citrus Flavonoids Cognitive Performance Randomized Trial | 1 2 Flavonoids are a class of naturally occurring polyphenolic compounds ubiquitously present in plants. | 3 | Cichon Natalia (2025) | Flavanones as Modulators of Gut Microbiota and Cognitive Function |
| Citrus Flavonoids Cognitive Performance Randomized Trial | These disorders are commonly associated with oxidative stress, mitochondrial dysfunction, and neuroinflammation, all of which contribute to neuronal damage and degeneration of brain function (). | 4 | Kim Hee Ju (2026) | Cognitive-Enhancing Effects of Hesperetin-Rich CNE against Neuronal Damage and Memory Impairment by Regulating AKT/Nrf2 and BDNF/CREB Signaling |
| Citrus Flavonoids Cognitive Performance Randomized Trial | However, excessive glutamate accumulation causes overstimulation of receptors, leading to calcium overload, increased production of reactive oxygen species (ROS), and neuronal death through oxidative stress-mediated apoptotic pathways (). | 4 | Kim Hee Ju (2026) | Cognitive-Enhancing Effects of Hesperetin-Rich CNE against Neuronal Damage and Memory Impairment by Regulating AKT/Nrf2 and BDNF/CREB Signaling |
| Citrus Flavonoids Cognitive Performance Randomized Trial | Flavonoids have been associated with a range of biological activities, including anti-inflammatory, antioxidant, anticancer, and respiratory protective effects (;).peel ethanol extract (CNE), a Korean traditional citrus variety cultivated on Jeju Island, South Korea, is rich in flavonoids and other phytochemicals known for their antioxidant and anti-inflammatory properties. | 4 | Kim Hee Ju (2026) | Cognitive-Enhancing Effects of Hesperetin-Rich CNE against Neuronal Damage and Memory Impairment by Regulating AKT/Nrf2 and BDNF/CREB Signaling |
| Citrus Flavonoids Cognitive Performance Randomized Trial | Kim, 2020 Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), are characterized by progressive loss of neurons, synaptic dysfunction, and cognitive decline. | 4 | Kim Hee Ju (2026) | Cognitive-Enhancing Effects of Hesperetin-Rich CNE against Neuronal Damage and Memory Impairment by Regulating AKT/Nrf2 and BDNF/CREB Signaling |
| Citrus Flavonoids Cognitive Performance Randomized Trial | Growing evidence highlights medicinal plants and their bioactive phytoconstituents as promising candidates for AD prevention and treatment because of their multitarget mechanisms, favorable safety profiles, and long history of traditional use. | 4 | Siam NH (2026) | Medicinal Plants and Their Bioactive Phytochemicals as Emerging Therapeutic Strategies for Alzheimer's Disease: An Integrative Review of Preclinical and Clinical Evidence. |
| Citrus Flavonoids Cognitive Performance Randomized Trial | This review aims to evaluate the neuroprotective potential of medicinal plants and their bioactive compounds in preventing and managing AD by summarizing evidence from in vitro, in vivo, and clinical studies. | 4 | Siam NH (2026) | Medicinal Plants and Their Bioactive Phytochemicals as Emerging Therapeutic Strategies for Alzheimer's Disease: An Integrative Review of Preclinical and Clinical Evidence. |
| Citrus Flavonoids Cognitive Performance Randomized Trial | Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid deposition, tau hyperphosphorylation, mitochondrial dysfunction, oxidative stress, neuroinflammation, and blood-brain barrier disruption, collectively leading to widespread cortical and subcortical atrophy. | 4 | Siam NH (2026) | Medicinal Plants and Their Bioactive Phytochemicals as Emerging Therapeutic Strategies for Alzheimer's Disease: An Integrative Review of Preclinical and Clinical Evidence. |
| Citrus Flavonoids Cognitive Performance Randomized Trial | Current FDA-approved pharmacotherapies, including acetylcholinesterase inhibitors and memantine, provide only modest symptomatic relief and fail to halt disease progression, underscoring the urgent need for alternative therapeutic approaches. | 4 | Siam NH (2026) | Medicinal Plants and Their Bioactive Phytochemicals as Emerging Therapeutic Strategies for Alzheimer's Disease: An Integrative Review of Preclinical and Clinical Evidence. |
Source documents