Is Multivitamin Cognitive Performance Randomized Trial safe?

Updated October 2026

Quick Answer

Multivitamin Cognitive Performance Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: The d emographic shift toward an older population is accelerating the prevalence of age-related diseases.

Key Takeaways

  • 01The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. [Kuerec AH (2026)]
  • 02Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. [Kuerec AH (2026)]
  • 03The multivitamin with guaraná treatment was associated with significantly enhanced Serial Threes performance and self-rated contentment. [Scholey A (2013)]
  • 04fMRI revealed that both multivitamin treatments increased activation in areas associated with working memory and attentional processing, with the effect being greater in the multivitamin with guaraná condition. [Scholey A (2013)]
The current Migaku evidence database contains 2 reusable source documents for Multivitamin Cognitive Performance Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. [Kuerec AH (2026); evidence level 2] - Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. [Kuerec AH (2026); evidence level 2] - The multivitamin with guaraná treatment was associated with significantly enhanced Serial Threes performance and self-rated contentment. [Scholey A (2013); evidence level 4] - fMRI revealed that both multivitamin treatments increased activation in areas associated with working memory and attentional processing, with the effect being greater in the multivitamin with guaraná condition. [Scholey A (2013); evidence level 4] - Furthermore, they demonstrate for the first time increased brain activation from multivitamin preparations both with and without guaraná, as measured using fMRI. [Scholey A (2013); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticals.
  2. Acute effects of different multivitamin mineral preparations with and without Guaraná on mood, cognitive performance and functional brain activation.