Is Melissa Sleep Quality Randomized Trial safe?

The current Migaku evidence database contains 2 reusable source documents for Melissa Sleep Quality Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Elevated or blunted cortisol levels have been associated with impaired sleep quality, heightened emotional distress, and reduced mental well-being in both clinical populations and non-clinical models (,,). [Mazzola Giuseppe (2026); evidence level 4] - Experimental models suggest that rosmarinic acid, the main bioactive compound of, can reduce stress-induced corticosterone elevations, which may translate into improved sleep architecture and psychological outcomes (,). [Mazzola Giuseppe (2026); evidence level 4] - 14 16 16 17 In a recent clinical study, 3 weeks of daily supplementation with Melissa extract formulated in phospholipids (Melissa Phytosome™, as Relissa™) was associated with significant improvements in sleep quality, depression, stress, affective states, and quality of life in adults with emotional distress at the daily dose of 400 mg (–). [Mazzola Giuseppe (2026); evidence level 4] - 1 5 1 2 6 Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, as reflected by altered diurnal cortisol secretion, is strongly implicated in the pathophysiology of sleep disturbances, mood disorders, and stress-related conditions (–). [Mazzola Giuseppe (2026); evidence level 4] - Historical use of medicinal plants was a result of cumulative trial and error experience and the transmission of traditional knowledge between generations, which later inspired systematic efforts to turn empirical claims into evidence-based arguments []. [Cîmpeanu Ioan-Alexandru (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.