evidence table

Melissa Sleep Quality Randomized Trial Evidence Table

Structured evidence table for Melissa Sleep Quality Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Melissa Sleep Quality Randomized TrialElevated or blunted cortisol levels have been associated with impaired sleep quality, heightened emotional distress, and reduced mental well-being in both clinical populations and non-clinical models (,,).4Mazzola Giuseppe (2026)Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
Melissa Sleep Quality Randomized TrialExperimental models suggest that rosmarinic acid, the main bioactive compound of, can reduce stress-induced corticosterone elevations, which may translate into improved sleep architecture and psychological outcomes (,).4Mazzola Giuseppe (2026)Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
Melissa Sleep Quality Randomized Trial14 16 16 17 In a recent clinical study, 3 weeks of daily supplementation with Melissa extract formulated in phospholipids (Melissa Phytosome™, as Relissa™) was associated with significant improvements in sleep quality, depression, stress, affective states, and quality of life in adults with emotional distress at the daily dose of 400 mg (–).4Mazzola Giuseppe (2026)Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
Melissa Sleep Quality Randomized Trial1 5 1 2 6 Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, as reflected by altered diurnal cortisol secretion, is strongly implicated in the pathophysiology of sleep disturbances, mood disorders, and stress-related conditions (–).4Mazzola Giuseppe (2026)Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
Melissa Sleep Quality Randomized TrialHistorical use of medicinal plants was a result of cumulative trial and error experience and the transmission of traditional knowledge between generations, which later inspired systematic efforts to turn empirical claims into evidence-based arguments [].4Cîmpeanu Ioan-Alexandru (2026)Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
Melissa Sleep Quality Randomized TrialAlso, standardization and phytochemical reporting is the preferred method for interpreting the evidence base across Lamiaceae, as its composition is influenced by genetics, geography, cultivation, and post-harvest handling [,].4Cîmpeanu Ioan-Alexandru (2026)Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
Melissa Sleep Quality Randomized TrialAccordingly, the present review mapsfrom botanical and phytochemical fundamentals through recent preclinical advances and available clinical evidence, with emphasis on endpoints that best support translation and reproducibility across study types.4Cîmpeanu Ioan-Alexandru (2026)Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
Melissa Sleep Quality Randomized Trial1 2 2 1 3 4 1 2 4 5 Traditional healing systems and contemporary natural products research still depend on medicinal and aromatic plants, which continue to provide structurally diverse bioactive compounds with broad therapeutic potential [,].4Cîmpeanu Ioan-Alexandru (2026)Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
topicMelissa Sleep Quality Randomized Trial
claimElevated or blunted cortisol levels have been associated with impaired sleep quality, heightened emotional distress, and reduced mental well-being in both clinical populations and non-clinical models (,,).
evidence level4
citationMazzola Giuseppe (2026)
sourceSalivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
topicMelissa Sleep Quality Randomized Trial
claimExperimental models suggest that rosmarinic acid, the main bioactive compound of, can reduce stress-induced corticosterone elevations, which may translate into improved sleep architecture and psychological outcomes (,).
evidence level4
citationMazzola Giuseppe (2026)
sourceSalivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
topicMelissa Sleep Quality Randomized Trial
claim14 16 16 17 In a recent clinical study, 3 weeks of daily supplementation with Melissa extract formulated in phospholipids (Melissa Phytosome™, as Relissa™) was associated with significant improvements in sleep quality, depression, stress, affective states, and quality of life in adults with emotional distress at the daily dose of 400 mg (–).
evidence level4
citationMazzola Giuseppe (2026)
sourceSalivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
topicMelissa Sleep Quality Randomized Trial
claim1 5 1 2 6 Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, as reflected by altered diurnal cortisol secretion, is strongly implicated in the pathophysiology of sleep disturbances, mood disorders, and stress-related conditions (–).
evidence level4
citationMazzola Giuseppe (2026)
sourceSalivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
topicMelissa Sleep Quality Randomized Trial
claimHistorical use of medicinal plants was a result of cumulative trial and error experience and the transmission of traditional knowledge between generations, which later inspired systematic efforts to turn empirical claims into evidence-based arguments [].
evidence level4
citationCîmpeanu Ioan-Alexandru (2026)
sourceMelissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
topicMelissa Sleep Quality Randomized Trial
claimAlso, standardization and phytochemical reporting is the preferred method for interpreting the evidence base across Lamiaceae, as its composition is influenced by genetics, geography, cultivation, and post-harvest handling [,].
evidence level4
citationCîmpeanu Ioan-Alexandru (2026)
sourceMelissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
topicMelissa Sleep Quality Randomized Trial
claimAccordingly, the present review mapsfrom botanical and phytochemical fundamentals through recent preclinical advances and available clinical evidence, with emphasis on endpoints that best support translation and reproducibility across study types.
evidence level4
citationCîmpeanu Ioan-Alexandru (2026)
sourceMelissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies
topicMelissa Sleep Quality Randomized Trial
claim1 2 2 1 3 4 1 2 4 5 Traditional healing systems and contemporary natural products research still depend on medicinal and aromatic plants, which continue to provide structurally diverse bioactive compounds with broad therapeutic potential [,].
evidence level4
citationCîmpeanu Ioan-Alexandru (2026)
sourceMelissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies

Learn next

Related evidence and supplement guides

SupplementGlycineNon-essential amino acid that cools core body temperature and deepens slow-wave sleep — remarkab...GuideMelissa Sleep Quality Randomized Trial: What the Evidence SaysMelissa Sleep Quality Randomized Trial has 2 source documents in the current Migaku evidence dat...GuideKiwi Sleep Quality Randomized Trial: What the Evidence SaysKiwi Sleep Quality Randomized Trial has 2 source documents in the current Migaku evidence databa...GuideApigenin Sleep Quality Randomized Trial: What the Evidence SaysApigenin Sleep Quality Randomized Trial has 1 source documents in the current Migaku evidence da...GuidePhosphatidylserine Sleep Quality Randomized Trial: What the Evidence SaysPhosphatidylserine Sleep Quality Randomized Trial has 2 source documents in the current Migaku e...AnswerDoes Melissa Sleep Quality Randomized Trial work?Melissa Sleep Quality Randomized Trial has evidence relevant to strength of evidence and what th...AnswerIs Melissa Sleep Quality Randomized Trial safe?Melissa Sleep Quality Randomized Trial has evidence relevant to safety, limits, and clinician-di...AnswerWhat does the evidence say about Melissa Sleep Quality Randomized Trial?Melissa Sleep Quality Randomized Trial has evidence relevant to benefits, uncertainty, and pract...

Source documents

  1. Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation
  2. Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies