evidence answer

Is Melatonin Sleep Quality Randomized Trial safe?

Updated July 2026

Quick Answer

Melatonin Sleep Quality Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: While exogenous melatonin supplements are used to manage the condition, there is limited evidence available on the efficacy of sustained-release (SR) melatonin formulations.

Key Takeaways

  • 01While exogenous melatonin supplements are used to manage the condition, there is limited evidence available on the efficacy of sustained-release (SR) melatonin formulations. [Thanawala S (2026)]
  • 02Supplementation with melatonin-SR 2 mg capsule at night for 28 days was found to be effective and safe in improving objective and subjective sleep quality outcomes and overall well-being in the trial population. [Thanawala S (2026)]
  • 03Sleep disturbances and poor sleep quality are growing public health concerns, adversely affecting both physical and mental health. [Thanawala S (2026)]
The current Migaku evidence database contains 1 reusable source document for Melatonin Sleep Quality Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - While exogenous melatonin supplements are used to manage the condition, there is limited evidence available on the efficacy of sustained-release (SR) melatonin formulations. [Thanawala S (2026); evidence level 2] - Supplementation with melatonin-SR 2 mg capsule at night for 28 days was found to be effective and safe in improving objective and subjective sleep quality outcomes and overall well-being in the trial population. [Thanawala S (2026); evidence level 2] - Sleep disturbances and poor sleep quality are growing public health concerns, adversely affecting both physical and mental health. [Thanawala S (2026); evidence level 2] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

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Sources

  1. Efficacy and Safety of Sustained-Release Melatonin Capsules (2 mg) in Healthy Adults with Poor Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial.