Quick Answer
Lysine Exercise Recovery Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time × treatment effect:< 0.001).
Key Takeaways
- 01Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time × treatment effect:< 0.001). [van Lieshout Glenn AA (2025)]
- 02In contrast, when lysine was excluded from the EAAs, plasma EAA-Lys concentrations for HIGH-GLYC were slightly higher compared with LOW-GLYC between 90 and 120 min (≤ 0.018 for both timepoints,E), but this did not result in a different iAUC between the protein treatments over the full postprandial period (= 1.00,F). [van Lieshout Glenn AA (2025)]
- 03As a result, peak lysine concentrations were 28% lower following ingestion of HIGH-GLYC compared with LOW-GLYC (191 ± 23 vs 266 ± 47 μmol · L, respectively,< 0.001). [van Lieshout Glenn AA (2025)]
- 041 2 2 [3] [4] [5] [6] [7] [8] [9] 10 10 [11] [12] [13] 14 15 16 8 WHO Muscle is a highly adaptive organ that is constantly turning over, i.e., muscle proteins are continually synthesized and degraded. [van Lieshout Glenn AA (2025)]
The current Migaku evidence database contains 2 reusable source documents for Lysine Exercise Recovery Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation.
- Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time × treatment effect:< 0.001). [van Lieshout Glenn AA (2025); evidence level 2]
- In contrast, when lysine was excluded from the EAAs, plasma EAA-Lys concentrations for HIGH-GLYC were slightly higher compared with LOW-GLYC between 90 and 120 min (≤ 0.018 for both timepoints,E), but this did not result in a different iAUC between the protein treatments over the full postprandial period (= 1.00,F). [van Lieshout Glenn AA (2025); evidence level 2]
- As a result, peak lysine concentrations were 28% lower following ingestion of HIGH-GLYC compared with LOW-GLYC (191 ± 23 vs 266 ± 47 μmol · L, respectively,< 0.001). [van Lieshout Glenn AA (2025); evidence level 2]
- 1 2 2 [3] [4] [5] [6] [7] [8] [9] 10 10 [11] [12] [13] 14 15 16 8 WHO Muscle is a highly adaptive organ that is constantly turning over, i.e., muscle proteins are continually synthesized and degraded. [van Lieshout Glenn AA (2025); evidence level 2]
- No significant differences for total amino acid concentrations between RBC and plasma were found. [Borges N (2024); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.
Sources
- Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial ☆
- Amino acid distribution in blood following high-intensity interval exercise: a preliminary study.