What does the evidence say about Lysine Exercise Recovery Randomized Trial?

Updated October 2026

Quick Answer

Lysine Exercise Recovery Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time &#215; treatment effect:< 0.001).

Key Takeaways

  • 01Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time &#215; treatment effect:< 0.001). [van Lieshout Glenn AA (2025)]
  • 02In contrast, when lysine was excluded from the EAAs, plasma EAA-Lys concentrations for HIGH-GLYC were slightly higher compared with LOW-GLYC between 90 and 120 min (&#8804; 0.018 for both timepoints,E), but this did not result in a different iAUC between the protein treatments over the full postprandial period (= 1.00,F). [van Lieshout Glenn AA (2025)]
  • 03As a result, peak lysine concentrations were 28% lower following ingestion of HIGH-GLYC compared with LOW-GLYC (191 &#177; 23 vs 266 &#177; 47 &#956;mol &#183; L, respectively,< 0.001). [van Lieshout Glenn AA (2025)]
  • 041 2 2 [3] [4] [5] [6] [7] [8] [9] 10 10 [11] [12] [13] 14 15 16 8 WHO Muscle is a highly adaptive organ that is constantly turning over, i.e., muscle proteins are continually synthesized and degraded. [van Lieshout Glenn AA (2025)]
The current Migaku evidence database contains 2 reusable source documents for Lysine Exercise Recovery Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - Plasma insulin concentrations increased following protein ingestion and were higher in the protein groups compared with PLA (time &#215; treatment effect:< 0.001). [van Lieshout Glenn AA (2025); evidence level 2] - In contrast, when lysine was excluded from the EAAs, plasma EAA-Lys concentrations for HIGH-GLYC were slightly higher compared with LOW-GLYC between 90 and 120 min (&#8804; 0.018 for both timepoints,E), but this did not result in a different iAUC between the protein treatments over the full postprandial period (= 1.00,F). [van Lieshout Glenn AA (2025); evidence level 2] - As a result, peak lysine concentrations were 28% lower following ingestion of HIGH-GLYC compared with LOW-GLYC (191 &#177; 23 vs 266 &#177; 47 &#956;mol &#183; L, respectively,< 0.001). [van Lieshout Glenn AA (2025); evidence level 2] - 1 2 2 [3] [4] [5] [6] [7] [8] [9] 10 10 [11] [12] [13] 14 15 16 8 WHO Muscle is a highly adaptive organ that is constantly turning over, i.e., muscle proteins are continually synthesized and degraded. [van Lieshout Glenn AA (2025); evidence level 2] - No significant differences for total amino acid concentrations between RBC and plasma were found. [Borges N (2024); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Milk Protein Glycation Compromises Postprandial Lysine Bioavailability but does not Modulate Postprandial Muscle Protein Synthesis Rates In Vivo in Males: A Double-blind, Randomized Parallel Trial &#9734;
  2. Amino acid distribution in blood following high-intensity interval exercise: a preliminary study.