What does the evidence say about Lactobacillus Casei Sleep Quality Randomized Trial?

Updated October 2026

Quick Answer

Lactobacillus Casei Sleep Quality Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Among these complaints, CKD-associated pruritus is particularly difficult to manage, since it is known to be multifactorial [].

Key Takeaways

  • 01Among these complaints, CKD-associated pruritus is particularly difficult to manage, since it is known to be multifactorial []. [Hung Kuo-Chin (2026)]
  • 02However, existing treatments for CKD-associated pruritus and sleep disturbance are frequently suboptimal and with variable efficacy. [Hung Kuo-Chin (2026)]
  • 03In a separate randomized, open-label study of patients receiving hemodialysis, LCR35, a form of freeze-dried, supplementation was associated with improvements in global Pittsburgh Sleep Quality Index (PSQI) scores and sleep duration, alterations in gut microbiota, and lower indoxyl sulfate (IS) concentrations []. [Hung Kuo-Chin (2026)]
  • 041 2 3 4 5 6 7 8 9 The symptom burden of chronic kidney disease (CKD) is heterogeneous and frequently under-recognized [,,]. [Hung Kuo-Chin (2026)]
The current Migaku evidence database contains 1 reusable source document for Lactobacillus Casei Sleep Quality Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - Among these complaints, CKD-associated pruritus is particularly difficult to manage, since it is known to be multifactorial []. [Hung Kuo-Chin (2026); evidence level 2] - However, existing treatments for CKD-associated pruritus and sleep disturbance are frequently suboptimal and with variable efficacy. [Hung Kuo-Chin (2026); evidence level 2] - In a separate randomized, open-label study of patients receiving hemodialysis, LCR35, a form of freeze-dried, supplementation was associated with improvements in global Pittsburgh Sleep Quality Index (PSQI) scores and sleep duration, alterations in gut microbiota, and lower indoxyl sulfate (IS) concentrations []. [Hung Kuo-Chin (2026); evidence level 2] - 1 2 3 4 5 6 7 8 9 The symptom burden of chronic kidney disease (CKD) is heterogeneous and frequently under-recognized [,,]. [Hung Kuo-Chin (2026); evidence level 2] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Exploratory Analysis of Pruritus and Sleep Outcomes After LCR35 Supplementation in Maintenance Hemodialysis: A Randomized, Open-Label Controlled Study