topicLactobacillus Casei Sleep Quality Randomized Trial
claimAmong these complaints, CKD-associated pruritus is particularly difficult to manage, since it is known to be multifactorial [].
evidence level2
citationHung Kuo-Chin (2026)
sourceExploratory Analysis of Pruritus and Sleep Outcomes After LCR35 Supplementation in Maintenance Hemodialysis: A Randomized, Open-Label Controlled Study
topicLactobacillus Casei Sleep Quality Randomized Trial
claimHowever, existing treatments for CKD-associated pruritus and sleep disturbance are frequently suboptimal and with variable efficacy.
evidence level2
citationHung Kuo-Chin (2026)
sourceExploratory Analysis of Pruritus and Sleep Outcomes After LCR35 Supplementation in Maintenance Hemodialysis: A Randomized, Open-Label Controlled Study
topicLactobacillus Casei Sleep Quality Randomized Trial
claimIn a separate randomized, open-label study of patients receiving hemodialysis, LCR35, a form of freeze-dried, supplementation was associated with improvements in global Pittsburgh Sleep Quality Index (PSQI) scores and sleep duration, alterations in gut microbiota, and lower indoxyl sulfate (IS) concentrations [].
evidence level2
citationHung Kuo-Chin (2026)
sourceExploratory Analysis of Pruritus and Sleep Outcomes After LCR35 Supplementation in Maintenance Hemodialysis: A Randomized, Open-Label Controlled Study
topicLactobacillus Casei Sleep Quality Randomized Trial
claim1 2 3 4 5 6 7 8 9 The symptom burden of chronic kidney disease (CKD) is heterogeneous and frequently under-recognized [,,].
evidence level2
citationHung Kuo-Chin (2026)
sourceExploratory Analysis of Pruritus and Sleep Outcomes After LCR35 Supplementation in Maintenance Hemodialysis: A Randomized, Open-Label Controlled Study