exercise performance

What does the evidence say about L-Citrulline Endurance Performance Meta-Analysis?

Updated October 2026

Quick Answer

L-Citrulline Endurance Performance Meta-Analysis has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: This study found no significant differences between the solutions and the placebo.

Key Takeaways

  • 01This study found no significant differences between the solutions and the placebo. [Ketelhut S (2025)]
  • 02Background The consumption of sports drinks before, during, and after endurance exercise is a common practice among athletes. [Ketelhut S (2025)]
  • 03These drinks typically contain a variety of components, each of which has been shown to offer individual benefits. [Ketelhut S (2025)]
  • 04Conclusion Acute ingestion of SPB after eight days may enhance blood flow, L-citrulline, and L-arginine plasma concentrations after high-intensity exercise, which may enhance performance. [Cabre HE (2023)]
The current Migaku evidence database contains 2 reusable source documents for L-Citrulline Endurance Performance Meta-Analysis. This answer focuses on benefits, uncertainty, and practical interpretation. - This study found no significant differences between the solutions and the placebo. [Ketelhut S (2025); evidence level 2] - Background The consumption of sports drinks before, during, and after endurance exercise is a common practice among athletes. [Ketelhut S (2025); evidence level 2] - These drinks typically contain a variety of components, each of which has been shown to offer individual benefits. [Ketelhut S (2025); evidence level 2] - Conclusion Acute ingestion of SPB after eight days may enhance blood flow, L-citrulline, and L-arginine plasma concentrations after high-intensity exercise, which may enhance performance. [Cabre HE (2023); evidence level 4] - Background Citrulline may amplify the effects of L-arginine and nitric oxide concentration, which may augment vasodilation and blood flow, thereby enhancing aerobic exercise performance. [Cabre HE (2023); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

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Sources

  1. Effect of different sports drink compositions on endurance performance and substrate oxidation: a randomized, double-blind, placebo-controlled crossover study in trained athletes.
  2. The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained males.