topicCitrulline Malate Muscle Soreness Meta-Analysis
claimSince lactate accumulation has been associated with muscle fatigue and soreness, the secondary outcome was to assess the effect of citrulline supplements on blood lactate levels after exercise.
evidence level1
citationRhim Hye Chang (2020)
sourceEffect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis
topicCitrulline Malate Muscle Soreness Meta-Analysis
claimThe quality of each article was assessed based on the Cochrane risk of bias tool for randomized controlled trials.Unpublished clinical trials were also searched using the term “citrulline” on ClinicalTrials.gov to identify any unpublished trials.
evidence level1
citationRhim Hye Chang (2020)
sourceEffect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis
topicCitrulline Malate Muscle Soreness Meta-Analysis
claimOther studies had a low risk for performance bias in that they masked placebo treatments by appearance and taste; in particular, 4 studies controlled for taste and smell by having participants wear a nose clip when consuming the supplement.
evidence level1
citationRhim Hye Chang (2020)
sourceEffect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis
topicCitrulline Malate Muscle Soreness Meta-Analysis
claimFirst, L-citrulline, one of the amino acids involved in the ureagenesis cycle, may facilitate the clearance of ammonia.
evidence level1
citationRhim Hye Chang (2020)
sourceEffect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis
topicCitrulline Malate Muscle Soreness Meta-Analysis
claimCK levels increased at 24 h post-exercise and remained elevate at 48 and 72 h, with no difference between CM and PL conditions.
evidence level4
citationda Silva DK (2017)
sourceCitrulline Malate Does Not Improve Muscle Recovery after Resistance Exercise in Untrained Young Adult Men.
topicCitrulline Malate Muscle Soreness Meta-Analysis
claimMuscle soreness increased at 24 h post-exercise, which progressively returned to baseline at 72 h in both conditions.
evidence level4
citationda Silva DK (2017)
sourceCitrulline Malate Does Not Improve Muscle Recovery after Resistance Exercise in Untrained Young Adult Men.
topicCitrulline Malate Muscle Soreness Meta-Analysis
claimLactate levels increased immediately post-exercise and remained elevated at 24, 48, and 72 h in both conditions.
evidence level4
citationda Silva DK (2017)
sourceCitrulline Malate Does Not Improve Muscle Recovery after Resistance Exercise in Untrained Young Adult Men.
topicCitrulline Malate Muscle Soreness Meta-Analysis
claimThe effects of citrulline malate (CM) on muscle recovery from resistance exercise remains unknown.
evidence level4
citationda Silva DK (2017)
sourceCitrulline Malate Does Not Improve Muscle Recovery after Resistance Exercise in Untrained Young Adult Men.