What does the evidence say about HMB Resistance Exercise Meta-Analysis?

The current Migaku evidence database contains 1 reusable source document for HMB Resistance Exercise Meta-Analysis. This answer focuses on benefits, uncertainty, and practical interpretation. - The Grading of Recommendations Assessment, Development, and Evaluation, Tool for the assEssment of Study qualiTy and reporting in EXercise, Rob 2, and Preferred Reporting Items for Systematic reviews and Meta-Analyses tools were used to evaluate the methodological quality and certainty of evidence. [Hernandez-Martinez J (2026); evidence level 1] - Four overall meta-analysis showed significant increases (P Conclusion ST combined with WP or HMB supplementation may contribute to improvements in fat-free mass and selected physical performance outcomes in older people with sarcopenia. [Hernandez-Martinez J (2026); evidence level 1] - However, the limited number of RCTs, relatively small sample sizes, moderate-to-high risk of bias, and inconsistent subgroup findings indicate that the current evidence should be interpreted cautiously and considered promising rather than definitive. [Hernandez-Martinez J (2026); evidence level 1] - Background Although previous studies have reported the benefits of combining physical activity with supplementation on body composition and physical performance in older people with sarcopenia, previous meta-analysis often included heterogeneous interventions, combining multiple types of supplements. [Hernandez-Martinez J (2026); evidence level 1] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.