Is Guarana Cognitive Performance Randomized Trial safe?

The current Migaku evidence database contains 3 reusable source documents for Guarana Cognitive Performance Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Despite variation in population-based habitual consumption, moderate long-term caffeine intake (up to 400 mg/day) is not linked to adverse effects on male fertility, behavior, cancer risk, calcium balance, or cardiovascular health []. [Hack Brian (2023); evidence level 1] - These include a range of health outcomes associated with reductions in chronic fatigue in cancer patients [,], short-term weight and fat loss [], and potentially protective effects against metabolic disorders in elderly subjects in habitual consumers []. [Hack Brian (2023); evidence level 1] - However, a recent meta-analysis established that chronic supplementation of guarana did not reduce perceived fatigue in cancer patients and the quality of experimental evidence was rated as low []. [Hack Brian (2023); evidence level 1] - 1 2 3 Nutritional ergogenic aids may increase human performance by different mechanisms. [Hack Brian (2023); evidence level 1] - Guarana significantly improved TMT-A performance compared with placebo ( p = 0.005, η 2 p = 0.05), whereas no significant differences were observed for TMT-B ( p = 0.08, η 2 p = 0.02). [Rekik S (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.