Does Glutamine Muscle Soreness Randomized Trial work?

Updated October 2026

Quick Answer

Glutamine Muscle Soreness Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: Purpose L-glutamine is the most abundant amino acid found in human muscle and plays an important role in protein synthesis and can reduce the levels of inflammation biomarkers and creatine kinase (CK) after training sessions.

Key Takeaways

  • 01Purpose L-glutamine is the most abundant amino acid found in human muscle and plays an important role in protein synthesis and can reduce the levels of inflammation biomarkers and creatine kinase (CK) after training sessions. [Rahmani-Nia F (2013)]
  • 02Delayed onset muscle soreness (DOMS) develops after intense exercise and is associated with an inflammatory response. [Rahmani-Nia F (2013)]
  • 03Conclusion The results of this study indicate that glutamine supplementation has no positive effect on muscle injury markers after a resistance training session. [Rahmani-Nia F (2013)]
  • 04Results There was no statistically significant difference between groups in perceived muscle soreness (SOR), ROM and EMG activity (P Conclusion The results indicate that L-glutamine supplementation has no significant effect on muscle injury markers in between groups, although glutamine supplementation attenuated delayed onset muscle soreness (DOMS) effects in sup group. [Rahmani Nia F (2013)]
The current Migaku evidence database contains 2 reusable source documents for Glutamine Muscle Soreness Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - Purpose L-glutamine is the most abundant amino acid found in human muscle and plays an important role in protein synthesis and can reduce the levels of inflammation biomarkers and creatine kinase (CK) after training sessions. [Rahmani-Nia F (2013); evidence level 4] - Delayed onset muscle soreness (DOMS) develops after intense exercise and is associated with an inflammatory response. [Rahmani-Nia F (2013); evidence level 4] - Conclusion The results of this study indicate that glutamine supplementation has no positive effect on muscle injury markers after a resistance training session. [Rahmani-Nia F (2013); evidence level 4] - Results There was no statistically significant difference between groups in perceived muscle soreness (SOR), ROM and EMG activity (P Conclusion The results indicate that L-glutamine supplementation has no significant effect on muscle injury markers in between groups, although glutamine supplementation attenuated delayed onset muscle soreness (DOMS) effects in sup group. [Rahmani Nia F (2013); evidence level 4] - Objective(s) The purpose of the present study was to examine the effects of L-glutamine on electromyographic (EMG) activity of the quadriceps muscle injured by eccentric exercise (EE). [Rahmani Nia F (2013); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Surface Electromyography Assessments of the Vastus medialis and Rectus femoris Muscles and Creatine Kinase after Eccentric Contraction Following Glutamine Supplementation.
  2. Effect of L-glutamine supplementation on electromyographic activity of the quadriceps muscle injured by eccentric exercise.