Is Creatine Sleep Deprivation Performance Randomized Trial safe?

The current Migaku evidence database contains 2 reusable source documents for Creatine Sleep Deprivation Performance Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - The present study investigates whether supplementation of a lower dose is associated with cognitive effects during sleep deprivation, focusing exclusively on cognitive performance outcomes. [Gordji-Nejad A (2026); evidence level 4] - Conclusions: Our results show that a dose of 0.2 g/kg creatine is associated with a reduced deterioration in cognitive performance during sleep deprivation. [Gordji-Nejad A (2026); evidence level 4] - Background/Objectives: Creatine is a supplement that, beyond its physiological effects, has been shown to have positive effects on cognitive abilities. [Gordji-Nejad A (2026); evidence level 4] - In our previous study, we showed that a single dose of 0.35 g/kg creatine induces changes in brain metabolism during sleep deprivation and reduces deterioration in cognitive performance. [Gordji-Nejad A (2026); evidence level 4] - Based on the hypothesis that a high extracellular creatine availability and increased intracellular energy consumption will temporarily increase the central creatine uptake, subjects were orally administered a high single dose of creatinemonohydrate (0.35 g/kg) while performing cognitive tests during sleep deprivation. [Gordji-Nejad A (2024); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.