topicCreatine Sleep Deprivation Performance Randomized Trial
claimThe present study investigates whether supplementation of a lower dose is associated with cognitive effects during sleep deprivation, focusing exclusively on cognitive performance outcomes.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Sleep Deprivation Performance Randomized Trial
claimConclusions: Our results show that a dose of 0.2 g/kg creatine is associated with a reduced deterioration in cognitive performance during sleep deprivation.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Sleep Deprivation Performance Randomized Trial
claimBackground/Objectives: Creatine is a supplement that, beyond its physiological effects, has been shown to have positive effects on cognitive abilities.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Sleep Deprivation Performance Randomized Trial
claimIn our previous study, we showed that a single dose of 0.35 g/kg creatine induces changes in brain metabolism during sleep deprivation and reduces deterioration in cognitive performance.
evidence level4
citationGordji-Nejad A (2026)
sourceSingle-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance.
topicCreatine Sleep Deprivation Performance Randomized Trial
claimBased on the hypothesis that a high extracellular creatine availability and increased intracellular energy consumption will temporarily increase the central creatine uptake, subjects were orally administered a high single dose of creatinemonohydrate (0.35 g/kg) while performing cognitive tests during sleep deprivation.
evidence level4
citationGordji-Nejad A (2024)
sourceSingle dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.
topicCreatine Sleep Deprivation Performance Randomized Trial
claimThe inverse effects of creatine supplementation and sleep deprivation on high energy phosphates, neural creatine, and cognitive performances suggest that creatine is a suitable candidate for reducing the negative effects of sleep deprivation.
evidence level4
citationGordji-Nejad A (2024)
sourceSingle dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.
topicCreatine Sleep Deprivation Performance Randomized Trial
claimWith this, the main obstacle is the limited exogenous uptake by the central nervous system (CNS), making creatine only effective over a long-term diet of weeks.
evidence level4
citationGordji-Nejad A (2024)
sourceSingle dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.