What does the evidence say about Citrulline Resistance Training Meta-Analysis?

Updated October 2026

Quick Answer

Citrulline Resistance Training Meta-Analysis has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Risk of bias, small-study effects, sensitivity analyses, and GRADE certainty were assessed.

Key Takeaways

  • 01Risk of bias, small-study effects, sensitivity analyses, and GRADE certainty were assessed. [Wang X (2026)]
  • 02CM supplementation was associated with a small improvement in overall exercise performance (g = 0.16, p = 0.01); however, prediction intervals were wide and statistical power was limited. [Wang X (2026)]
  • 03Current evidence appeared more stable for acute than chronic supplementation, although the protocol subgroup difference remained uncertain. [Wang X (2026)]
  • 04Background: Citrulline malate (CM) is commonly used as an ergogenic supplement, but its effects on exercise performance and perceived exertion remain uncertain. [Wang X (2026)]
The current Migaku evidence database contains 2 reusable source documents for Citrulline Resistance Training Meta-Analysis. This answer focuses on benefits, uncertainty, and practical interpretation. - Risk of bias, small-study effects, sensitivity analyses, and GRADE certainty were assessed. [Wang X (2026); evidence level 1] - CM supplementation was associated with a small improvement in overall exercise performance (g = 0.16, p = 0.01); however, prediction intervals were wide and statistical power was limited. [Wang X (2026); evidence level 1] - Current evidence appeared more stable for acute than chronic supplementation, although the protocol subgroup difference remained uncertain. [Wang X (2026); evidence level 1] - Background: Citrulline malate (CM) is commonly used as an ergogenic supplement, but its effects on exercise performance and perceived exertion remain uncertain. [Wang X (2026); evidence level 1] - Exercise is low cost and biologically plausible, but evidence on its association with fertility-related outcomes is dispersed across multiple meta-analyses. [Lam LK (2026); evidence level 3] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Effects of Citrulline Malate Supplementation on Exercise Performance: A Systematic Review and Three-Level Meta-Analysis.
  2. Exercise intervention improves fertility outcomes in females and males: an umbrella review of meta-analyses.