Structured evidence table for L-Citrulline Resistance Exercise Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| L-Citrulline Resistance Exercise Randomized Trial | Although generally considered safe, their combined use with high-intensity training may increase the risk of exertional rhabdomyolysis and secondary liver or kidney injury. | 4 | Chowaniec P (2026) | Exercise-Induced Rhabdomyolysis With Supplements (Creatine, β-Alanine, Citrulline Malate, and β-Ecdysterone). |
| L-Citrulline Resistance Exercise Randomized Trial | Laboratory evaluation revealed markedly elevated creatine kinase (>120,000 U/L) and increased aminotransferases (aspartate aminotransferase (AST) 1,275 U/L; alanine aminotransferase (ALT) 337 U/L), with preserved renal function (creatinine 1.0 mg/dL; estimated glomerular filtration rate (eGFR) 108 mL/min/1.73 m²). | 4 | Chowaniec P (2026) | Exercise-Induced Rhabdomyolysis With Supplements (Creatine, β-Alanine, Citrulline Malate, and β-Ecdysterone). |
| L-Citrulline Resistance Exercise Randomized Trial | Creatine and β-alanine enhance exercise capacity through complementary mechanisms involving adenosine triphosphate (ATP) resynthesis and intracellular buffering, potentially enabling greater training loads and increasing risk of muscle injury. | 4 | Chowaniec P (2026) | Exercise-Induced Rhabdomyolysis With Supplements (Creatine, β-Alanine, Citrulline Malate, and β-Ecdysterone). |
| L-Citrulline Resistance Exercise Randomized Trial | Dietary supplements such as creatine, β-alanine, citrulline malate (CM), phosphatidic acid (PA), and β-ecdysterone are widely used to enhance exercise performance and muscle hypertrophy. | 4 | Chowaniec P (2026) | Exercise-Induced Rhabdomyolysis With Supplements (Creatine, β-Alanine, Citrulline Malate, and β-Ecdysterone). |
| L-Citrulline Resistance Exercise Randomized Trial | 1 2 3 4 2 5 6 L-citrulline is a non-essential amino acid that is found primarily in watermelons, cucumbers, and other melons []. | 4 | Gonzalez Adam M. (2023) | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
| L-Citrulline Resistance Exercise Randomized Trial | For this reason, L-citrulline has garnered much attention as a potential performance-enhancing dietary supplement over the last decade [], and it is currently among the most popular ingredients found in commercially available multi-ingredient pre-workout supplements, which are designed to improve exercise performance []. | 4 | Gonzalez Adam M. (2023) | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
| L-Citrulline Resistance Exercise Randomized Trial | Malate is an intermediate of the citric acid cycle that has been postulated to work synergistically with L-citrulline by upregulating oxidative ATP production during exercise, yet this lacks experimental evidence []. | 4 | Gonzalez Adam M. (2023) | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
| L-Citrulline Resistance Exercise Randomized Trial | Due to its ability to be converted to L-arginine via the urea cycle, L-citrulline serves as a nitric oxide (NO) precursor with the potential to increase blood flow and augment resistance exercise performance []. | 4 | Gonzalez Adam M. (2023) | Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance and Muscle Oxygenation in Recreationally Resistance Trained Men and Women |
Source documents