Is Citrulline Malate Resistance Training Randomized Trial safe?

The current Migaku evidence database contains 2 reusable source documents for Citrulline Malate Resistance Training Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - The primary physiological effect of NO during exercise is vasodilation, leading to an increased supply of oxygen and energy substrates to muscle tissues [,]. [Bayat Davoud (2025); evidence level 2] - Most of the ergogenic properties of CIT supplements are attributed to LC’s role as an L-arginine precursor, which leads to increased L-arginine bioavailability and enhanced NO production. [Bayat Davoud (2025); evidence level 2] - Only those individuals were allowed to participate in the study who were considered low risk by the American College of Sports Medicine [], were nonsmokers, had not used any ergogenic supplements for 8 weeks prior to enrollment, and had no orthopedic problems or metabolic disorders that could interfere with the outcome measures or full commitment to the study protocol. [Bayat Davoud (2025); evidence level 2] - 1 1 2 3 4 L-Citrulline (LC) is a non-essential, non-proteinogenic amino acid that has gained popularity as a Nitric Oxide (NO) enhancer in sports nutrition []. [Bayat Davoud (2025); evidence level 2] - Although generally considered safe, their combined use with high-intensity training may increase the risk of exertional rhabdomyolysis and secondary liver or kidney injury. [Chowaniec P (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.