exercise performance

Citrulline Malate Resistance Training Randomized Trial Evidence Table

Name: Citrulline Malate Resistance Training Randomized Trial Evidence Table
Creator: Migaku

Structured evidence table for Citrulline Malate Resistance Training Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Citrulline Malate Resistance Training Randomized Trial	The primary physiological effect of NO during exercise is vasodilation, leading to an increased supply of oxygen and energy substrates to muscle tissues [,].	2	Bayat Davoud (2025)	Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial
Citrulline Malate Resistance Training Randomized Trial	Most of the ergogenic properties of CIT supplements are attributed to LC’s role as an L-arginine precursor, which leads to increased L-arginine bioavailability and enhanced NO production.	2	Bayat Davoud (2025)	Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial
Citrulline Malate Resistance Training Randomized Trial	Only those individuals were allowed to participate in the study who were considered low risk by the American College of Sports Medicine [], were nonsmokers, had not used any ergogenic supplements for 8 weeks prior to enrollment, and had no orthopedic problems or metabolic disorders that could interfere with the outcome measures or full commitment to the study protocol.	2	Bayat Davoud (2025)	Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial
Citrulline Malate Resistance Training Randomized Trial	1 1 2 3 4 L-Citrulline (LC) is a non-essential, non-proteinogenic amino acid that has gained popularity as a Nitric Oxide (NO) enhancer in sports nutrition [].	2	Bayat Davoud (2025)	Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial
Citrulline Malate Resistance Training Randomized Trial	Although generally considered safe, their combined use with high-intensity training may increase the risk of exertional rhabdomyolysis and secondary liver or kidney injury.	4	Chowaniec P (2026)	Exercise-Induced Rhabdomyolysis With Supplements (Creatine, β-Alanine, Citrulline Malate, and β-Ecdysterone).
Citrulline Malate Resistance Training Randomized Trial	Laboratory evaluation revealed markedly elevated creatine kinase (>120,000 U/L) and increased aminotransferases (aspartate aminotransferase (AST) 1,275 U/L; alanine aminotransferase (ALT) 337 U/L), with preserved renal function (creatinine 1.0 mg/dL; estimated glomerular filtration rate (eGFR) 108 mL/min/1.73 m²).	4	Chowaniec P (2026)	Exercise-Induced Rhabdomyolysis With Supplements (Creatine, β-Alanine, Citrulline Malate, and β-Ecdysterone).
Citrulline Malate Resistance Training Randomized Trial	Creatine and β-alanine enhance exercise capacity through complementary mechanisms involving adenosine triphosphate (ATP) resynthesis and intracellular buffering, potentially enabling greater training loads and increasing risk of muscle injury.	4	Chowaniec P (2026)	Exercise-Induced Rhabdomyolysis With Supplements (Creatine, β-Alanine, Citrulline Malate, and β-Ecdysterone).
Citrulline Malate Resistance Training Randomized Trial	Dietary supplements such as creatine, β-alanine, citrulline malate (CM), phosphatidic acid (PA), and β-ecdysterone are widely used to enhance exercise performance and muscle hypertrophy.	4	Chowaniec P (2026)	Exercise-Induced Rhabdomyolysis With Supplements (Creatine, β-Alanine, Citrulline Malate, and β-Ecdysterone).