Is Citrulline Malate Resistance Exercise Randomized Trial safe?

The current Migaku evidence database contains 2 reusable source documents for Citrulline Malate Resistance Exercise Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Interpretation is further complicated by previous evidence syntheses that pooled studies of pure L-citrulline with CM, thereby limiting conclusions specific to CM supplementation [,,]. [Wang Xuexiang (2026); evidence level 1] - In contrast, Aguiar & Casonatto (2022) [] focused exclusively on maximal muscular strength in resistance-trained adults incorporating four trials without distinguishing between acute and chronic supplementation protocols, and found no performance benefits. [Wang Xuexiang (2026); evidence level 1] - These reviews therefore reach divergent conclusions and each addresses only a narrow aspect of the available evidence []. [Wang Xuexiang (2026); evidence level 1] - 1 2 3 4 5 6 2 Citrulline malate (CM) is a popular dietary supplement marketed as an ergogenic aid for exercise performance []. [Wang Xuexiang (2026); evidence level 1] - These changes include endothelial dysfunction, reduced nitric oxide (NO) bioavailability, increased arterial stiffness, loss of skeletal muscle mass and strength, and unfavorable shifts in body composition (Cauley, Albu et al.). [Chen Zhigang (2026); evidence level 3] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.