topicCitrulline Resistance Exercise Randomized Trial
claimThese changes include endothelial dysfunction, reduced nitric oxide (NO) bioavailability, increased arterial stiffness, loss of skeletal muscle mass and strength, and unfavorable shifts in body composition (Cauley, Albu et al.).
evidence level3
citationChen Zhigang (2026)
sourceL-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
topicCitrulline Resistance Exercise Randomized Trial
claimFrom a vascular perspective, postmenopausal women frequently exhibit impaired endothelial-dependent vasodilation and increased central arterial stiffness, both of which contribute to exaggerated blood pressure responses during daily physical activity (Moreau and Hildreth).
evidence level3
citationChen Zhigang (2026)
sourceL-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
topicCitrulline Resistance Exercise Randomized Trial
claimReduced NO production, driven by diminished estrogen signaling and age-related endothelial dysfunction, plays a central role in these changes.
evidence level3
citationChen Zhigang (2026)
sourceL-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women
topicCitrulline Resistance Exercise Randomized Trial
claim2023 2012 2013 2003 2014 2009 2008 Menopause is the permanent cessation of menstrual cycles, typically occurring around 45–55 years of age, marking the end of a woman’s reproductive period.
evidence level3
citationChen Zhigang (2026)
sourceL-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women