Is Calcium Sleep Meta-Analysis safe?

The current Migaku evidence database contains 2 reusable source documents for Calcium Sleep Meta-Analysis. This answer focuses on safety, limits, and clinician-discussion contexts. - Evidence review A systematic literature review and meta-analysis were conducted using PubMed/MEDLINE, Embase, and Web of Science (2015-2024), following PRISMA guidelines. [Du J (2026); evidence level 1] - Conclusion Available evidence suggests that melatonin-containing supplements may be associated with improved BMD in menopausal women, but the independent effect of melatonin and an optimal dose remain unclear due to heterogeneity in interventions and the prevalent use of combination therapies. [Du J (2026); evidence level 1] - For other outcomes (sleep, menopausal symptoms, mood, sexual function, BMI, and insulin), the evidence is currently inconclusive. [Du J (2026); evidence level 1] - Objective This study evaluated the impact of melatonin supplementation on bone mineral density (BMD), sleep quality, menopausal symptoms, mood, sexual function, serum insulin levels, and body mass index in menopausal women. [Du J (2026); evidence level 1] - Furthermore, several modifiable risk factors such as hypertension, diabetes, obesity, smoking, and sedentary lifestyle play a key role in the development and progression of this disease []. [Kusyn Natalia (2026); evidence level 3] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.