Structured evidence table for Calcium Sleep Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Calcium Sleep Meta-Analysis | Evidence review A systematic literature review and meta-analysis were conducted using PubMed/MEDLINE, Embase, and Web of Science (2015-2024), following PRISMA guidelines. | 1 | Du J (2026) | A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women. |
| Calcium Sleep Meta-Analysis | Conclusion Available evidence suggests that melatonin-containing supplements may be associated with improved BMD in menopausal women, but the independent effect of melatonin and an optimal dose remain unclear due to heterogeneity in interventions and the prevalent use of combination therapies. | 1 | Du J (2026) | A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women. |
| Calcium Sleep Meta-Analysis | For other outcomes (sleep, menopausal symptoms, mood, sexual function, BMI, and insulin), the evidence is currently inconclusive. | 1 | Du J (2026) | A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women. |
| Calcium Sleep Meta-Analysis | Objective This study evaluated the impact of melatonin supplementation on bone mineral density (BMD), sleep quality, menopausal symptoms, mood, sexual function, serum insulin levels, and body mass index in menopausal women. | 1 | Du J (2026) | A systematic review and meta-analysis of randomized controlled trials investigated the effects of melatonin supplementation on bone mineral density, quality of life, and sleep in menopausal women. |
| Calcium Sleep Meta-Analysis | Furthermore, several modifiable risk factors such as hypertension, diabetes, obesity, smoking, and sedentary lifestyle play a key role in the development and progression of this disease []. | 3 | Kusyn Natalia (2026) | Well-Known and Novel Behavioural Risk Factors for Heart Failure |
| Calcium Sleep Meta-Analysis | This review summarizes the epidemiology of HF and discusses the pathophysiological links between its primary causes and risk factors, highlighting the path of future research required on this topic. | 3 | Kusyn Natalia (2026) | Well-Known and Novel Behavioural Risk Factors for Heart Failure |
| Calcium Sleep Meta-Analysis | The search strategy included various key terms such as heart failure, HF risk factors, and lifestyle determinants, in combination with key terms such as tobacco smoking, electronic nicotine delivery systems, e-cigarettes, alcohol consumption, illicit drugs, cocaine, cannabis, caffeine, sleep disorders, psychological stress, obesity, dietary patterns, physical activity and vitamin deficiencies. | 3 | Kusyn Natalia (2026) | Well-Known and Novel Behavioural Risk Factors for Heart Failure |
| Calcium Sleep Meta-Analysis | 1 2 3 4 1 3 5 1 1 Figure 1 Heart failure (HF) is a complex clinical syndrome characterized by structural or functional cardiac abnormalities that impair ventricular filling or blood ejection, which leads to inadequate systemic perfusion and elevates intracardiac pressures [,,,]. | 3 | Kusyn Natalia (2026) | Well-Known and Novel Behavioural Risk Factors for Heart Failure |
Source documents