Structured evidence table for Zinc Mood Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Zinc Mood Randomized Trial | 1 2 3 4 1 4 5 6 7 L-carnosine (β-alanyl-L-histidine) is a naturally occurring bioactive dipeptide composed of β-alanine and L-histidine, predominantly found in tissues with high metabolic demands such as skeletal muscle and the central nervous system [,]. | 1 | Hsiao Yung-Fang (2026) | The Effects of Carnosine on Cognitive Function and Mental Health—A Systematic Review and Meta-Analysis |
| Zinc Mood Randomized Trial | Age-associated declines in muscle carnosine content have been associated with reduced exercise capacity and increased fatigue, whereas reductions in brain carnosine levels have been linked to oxidative damage, protein aggregation, and cognitive impairment in neurodegenerative conditions or aging [,,]. | 1 | Hsiao Yung-Fang (2026) | The Effects of Carnosine on Cognitive Function and Mental Health—A Systematic Review and Meta-Analysis |
| Zinc Mood Randomized Trial | The goal of this scoping review is to identify research areas for which sufficient evidence warrants a systematic review (SR) and meta-analysis. | 1 | Hsiao Yung-Fang (2026) | The Effects of Carnosine on Cognitive Function and Mental Health—A Systematic Review and Meta-Analysis |
| Zinc Mood Randomized Trial | Mediated by carnosine synthase, the endogenous synthesis of L-carnosine is rate-limited by the availability of β-alanine [,]. | 1 | Hsiao Yung-Fang (2026) | The Effects of Carnosine on Cognitive Function and Mental Health—A Systematic Review and Meta-Analysis |
| Zinc Mood Randomized Trial | A comprehensive review of psychiatric presentations reported that psychiatric symptoms span attention problems, anxiety, mood/behavioral disorders, and psychosis and identified > 100 IEMs associated with psychiatric manifestations; in a curated analysis, 94 IEMs were linked to psychiatric symptoms, with mood changes ranging from depressive syndromes to bipolar-like presentations []. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Zinc Mood Randomized Trial | 6 7 Clinically, mood disorders associated with IEMs often exhibit characteristic diagnostic patterns that may aid early recognition. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Zinc Mood Randomized Trial | When methylation capacity is constrained, through low folate/B12 status, reduced enzyme function (e.g., MTHFR variants), inflammation, oxidative stress, alcohol use, or high metabolic demand, homocysteine can rise, and SAMe availability can fall, creating a low methylation status that plausibly amplifies emotional volatility via neurotransmitter and epigenetic pathways []. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Zinc Mood Randomized Trial | 1 2 Depression and anxiety disorders are leading contributors to global disability. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
Source documents