evidence table
Zinc Immune Meta-Analysis Evidence Table
Structured evidence table for Zinc Immune Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Zinc Immune Meta-Analysis | Zinc deficiency has been associated with impaired immune responses, increased oxidative stress, compromised intestinal barrier function, and delayed wound healing-all of which are particularly relevant in the pathophysiology and management of IBD [,]. | 1 | Muacevic Alexander (2026) | Zinc Deficiency Among Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| Zinc Immune Meta-Analysis | 10 11 12 13 14 Multiple mechanisms contribute to zinc deficiency in IBD patients, including reduced dietary intake due to food aversions and restrictive diets, malabsorption secondary to intestinal inflammation and mucosal damage, increased gastrointestinal losses through diarrhea and protein-losing enteropathy, and drug-nutrient interactions with medications such as sulfasalazine and corticosteroids [,]. | 1 | Muacevic Alexander (2026) | Zinc Deficiency Among Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| Zinc Immune Meta-Analysis | Between-study heterogeneity was evaluated using Cochran’s Q test (with p<0.10 considered evidence of significant heterogeneity) and quantified using the I² statistic, where values above 75% reflected high heterogeneity, 50-75% represented moderate heterogeneity, and values below 50% indicated low heterogeneity. | 1 | Muacevic Alexander (2026) | Zinc Deficiency Among Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| Zinc Immune Meta-Analysis | 1 2 3 4 Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), comprises a group of chronic inflammatory conditions of the gastrointestinal tract characterized by a relapsing-remitting course, with a global prevalence estimated at 0.3% in Western populations and rising incidence in newly industrialized countries [,]. | 1 | Muacevic Alexander (2026) | Zinc Deficiency Among Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| Zinc Immune Meta-Analysis | During pregnancy, zinc supplementation is frequently recommended to enhance maternal immunity, reduce the risk of infections, and support overall gestational health (). | 3 | Mugundan Uma Maheshwari (2026) | Could excessive zinc supplementation during pregnancy cause menkes disease? A hypothesis worth investigating |
| Zinc Immune Meta-Analysis | However, direct clinical evidence remains limited, with only a small number of studies in pregnant women demonstrating an inverse relationship between zinc supplementation and copper status and no large-scale epidemiological data linking this interaction to neonatal outcomes. | 3 | Mugundan Uma Maheshwari (2026) | Could excessive zinc supplementation during pregnancy cause menkes disease? A hypothesis worth investigating |
| Zinc Immune Meta-Analysis | As a result, excessive zinc consumption can indirectly cause copper deficiency even if copper intake remains adequate, which is depicted in. | 3 | Mugundan Uma Maheshwari (2026) | Could excessive zinc supplementation during pregnancy cause menkes disease? A hypothesis worth investigating |
| Zinc Immune Meta-Analysis | 1 2 Menkes disease (MD) is a rare X-linked recessive neurodegenerative disorder caused by mutations in the ATP7A gene, which encodes a critical copper-transporting ATPase involved in cellular copper efflux and distribution. | 3 | Mugundan Uma Maheshwari (2026) | Could excessive zinc supplementation during pregnancy cause menkes disease? A hypothesis worth investigating |
Source documents