topicVitamin A Skin Health Randomized Trial
claimIt contributes to millions of deaths each year and is strongly associated with comorbidities such as hypertension, type 2 diabetes, and cardiovascular disease.In Brazil, the burden is similarly substantial, with 39.6% of the population classified as overweight and 23.8% as obese.The rising prevalence of obesity highlights the need to identify modifiable risk factors and develop effective interventions.
evidence level2
citationMenezes-Júnior Luiz (2026)
sourceVitamin D supplementation and central adiposity in male shift workers: a randomized clinical trial on metabolic health
topicVitamin A Skin Health Randomized Trial
claim8 9 Shift workers are particularly vulnerable because reduced sunlight exposure limits endogenous vitamin D synthesis.
evidence level2
citationMenezes-Júnior Luiz (2026)
sourceVitamin D supplementation and central adiposity in male shift workers: a randomized clinical trial on metabolic health
topicVitamin A Skin Health Randomized Trial
claimStudies have shown that shift workers have an 80% higher risk of hypovitaminosis D than individuals in other occupational groups.In this population, Batista et al.reported a high prevalence of hypovitaminosis D (73%) and a significant association with increased visceral fat area (odds ratio [OR]: 2.4; 95% confidence interval [CI]: 1.1–5.2).
evidence level2
citationMenezes-Júnior Luiz (2026)
sourceVitamin D supplementation and central adiposity in male shift workers: a randomized clinical trial on metabolic health
topicVitamin A Skin Health Randomized Trial
claim1 2 Obesity is a chronic, multifactorial disease characterized by excessive adipose tissue accumulation and is among the most significant global public health challenges.
evidence level2
citationMenezes-Júnior Luiz (2026)
sourceVitamin D supplementation and central adiposity in male shift workers: a randomized clinical trial on metabolic health
topicVitamin A Skin Health Randomized Trial
claimAD is now recognized as one of the most common dermatologic conditions worldwide, which is frequently associated with food and environmental allergies [].
evidence level3
citationCardenas Caitlyn (2026)
sourceThe Role of Fat-Soluble Vitamins in the Prevention and Management of Atopic Dermatitis
topicVitamin A Skin Health Randomized Trial
claimAlthough AD affects cutaneous manifestations, it can substantially affect sleep and psychosocial well-being and is associated with an increased risk of other allergic diseases, including asthma and allergic rhinitis [,].
evidence level3
citationCardenas Caitlyn (2026)
sourceThe Role of Fat-Soluble Vitamins in the Prevention and Management of Atopic Dermatitis
topicVitamin A Skin Health Randomized Trial
claimEpidermal barrier dysfunction could be associated with filaggrin mutations, reduced ceramide levels, and increased trans-epidermal water loss.
evidence level3
citationCardenas Caitlyn (2026)
sourceThe Role of Fat-Soluble Vitamins in the Prevention and Management of Atopic Dermatitis
topicVitamin A Skin Health Randomized Trial
claim1 2 3 4 5 6 7 8 9 Atopic dermatitis (AD) is a chronic, relapsing inflammatory disorder characterized by pruritus, dryness, and eczematous lesions [].
evidence level3
citationCardenas Caitlyn (2026)
sourceThe Role of Fat-Soluble Vitamins in the Prevention and Management of Atopic Dermatitis