topicValerian Root Sleep Meta-Analysis
claimThese nocturnal difficulties are frequently accompanied by pronounced daytime impairments that impede optimal functioning, including fatigue, mood instability, and reduced concentration.
evidence level3
citationYang Shurui (2026)
sourceValeriana species and insomnia: multi-organ mechanisms and translational perspectives
topicValerian Root Sleep Meta-Analysis
claimInsomnia can present as a standalone condition or co-occur with other medical and mental health disorders, posing a risk for their progression or exacerbation if untreated (Perlis et al.; Riemann et al.).
evidence level3
citationYang Shurui (2026)
sourceValeriana species and insomnia: multi-organ mechanisms and translational perspectives
topicValerian Root Sleep Meta-Analysis
claimAlthough some medications are effective for treating acute insomnia, many approved options, including benzodiazepines, zaleplon, zolpidem, and eszopiclone, are associated with poor tolerability and limited data regarding their long-term effects (De Crescenzo et al.).
evidence level3
citationYang Shurui (2026)
sourceValeriana species and insomnia: multi-organ mechanisms and translational perspectives
topicValerian Root Sleep Meta-Analysis
claim2023 2022 2022 2022 2022 2022 2022 2022 The increasing prevalence of insomnia among adults, particularly in aging populations, is significantly diminishing quality of life.
evidence level3
citationYang Shurui (2026)
sourceValeriana species and insomnia: multi-organ mechanisms and translational perspectives
topicValerian Root Sleep Meta-Analysis
claimSleep is a complex biological process whose evolutionary purpose has remained equivocal for quite some time.More recently, however, compelling evidence has emerged, leading to recognition of the numerous metabolic and physiological functions sleep contributes to and actively supports.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicValerian Root Sleep Meta-Analysis
claimEpidemiological studies have revealed that sleep deprivation is associated with an increased risk of all-cause mortality,alongside numerous chronic conditions imposing a heavy burden on our healthcare and socioeconomic systems alike,including cardiovascular disease, stroke, obesity, type 2 diabetes, and various types of cancer and neurological disorders.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicValerian Root Sleep Meta-Analysis
claimThe scope of this narrative review is to summarize the available evidence on the mechanisms of action and potential benefits of the above-listed nutrients in the context of acute or chronic sleep disturbances.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicValerian Root Sleep Meta-Analysis
claim, , Over the past few decades, there has been an increasing appreciation of the negative impact of sleep disturbances and circadian misalignments on all aspects of human health and performance, ranging from objective alertness, learning, memory, and cognition to emotional regulation, social wellbeing and, most remarkably, physical health.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review