Structured evidence table for Urolithin A Muscle Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Urolithin A Muscle Randomized Trial | Sleep is vital to human health, and poor sleep health has been associated with numerous chronic conditions, including cardiovascular disease, obesity, depression, and type 2 diabetes. | 3 | Pinaffi-Langley ACDC (2026) | Potential impact of urolithin A on pathways relevant to sleep health: a mini review. |
| Urolithin A Muscle Randomized Trial | Thus, this mini review aimed to summarize the current evidence on the effect of urolithin A on sleep-relevant pathways and to explore the possible mechanisms underlying this effect. | 3 | Pinaffi-Langley ACDC (2026) | Potential impact of urolithin A on pathways relevant to sleep health: a mini review. |
| Urolithin A Muscle Randomized Trial | Although no study directly investigating the effect of urolithin A on sleep outcomes was identified, our search found four preclinical studies that included outcomes relevant to sleep. | 3 | Pinaffi-Langley ACDC (2026) | Potential impact of urolithin A on pathways relevant to sleep health: a mini review. |
| Urolithin A Muscle Randomized Trial | Recently, an emerging area of research has focused on the relationship between dietary polyphenols and sleep health. | 3 | Pinaffi-Langley ACDC (2026) | Potential impact of urolithin A on pathways relevant to sleep health: a mini review. |
| Urolithin A Muscle Randomized Trial | At 5 μM (RNA-seq), UA increased NOTCH1 (+73%), MYMX (+70%), PANX1 (+50%) and MSTN (+64%), and decreased FGF9 (-75%), ICAM5 (-52%) and MRLN (-33%), whereas UB decreased IGFN1 (-75%), TGFBI (-60%) and STC2 (-35%) and increased TGM2 (+59%). | 4 | Henrotin Y (2026) | Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes. |
| Urolithin A Muscle Randomized Trial | UA increased LIF (+80%) and decreased PTGS1 (-41%) and IL17B (-49%), whereas UB decreased PTGS1 (-43%) and increased IL17B (+45%). | 4 | Henrotin Y (2026) | Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes. |
| Urolithin A Muscle Randomized Trial | Both UA and UB reduced TGFBI protein levels dose-dependently (UA r 2 = 0.8582; UB r 2 = 0.7415). | 4 | Henrotin Y (2026) | Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes. |
| Urolithin A Muscle Randomized Trial | Background Urolithin A (UA) and urolithin B (UB) are gut microbiota-derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. | 4 | Henrotin Y (2026) | Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes. |
Source documents