Structured evidence table for Spermidine Cognition Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Spermidine Cognition Meta-Analysis | 1 2 Population aging has emerged as one of the greatest global healthcare challenges of the twenty-first century, accompanied by a rapid increase in age-associated disorders, particularly cognitive impairment and neurodegenerative diseases such as Alzheimer’s disease (AD). | 3 | Bhatia Muskan (2026) | Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health |
| Spermidine Cognition Meta-Analysis | 3 4 There is recent evidence to indicate that the gut microbiota plays an important role in healthy aging as a result of its wide-ranging interactions with host metabolism, immune function, the integrity of the intestinal barrier, and neuroendocrine signaling. | 3 | Bhatia Muskan (2026) | Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health |
| Spermidine Cognition Meta-Analysis | As a result, changes in the composition and function of gut microorganisms have been connected to biological aging and cognitive resilience. | 3 | Bhatia Muskan (2026) | Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health |
| Spermidine Cognition Meta-Analysis | Aging is characterized by a progressive decline in physiological function driven by interconnected molecular mechanisms, including cellular senescence, epigenetic alterations, oxidative stress, chronic low-grade inflammation [inflammaging], mitochondrial dysfunction, and metabolic dysregulation [,]. | 3 | Bhatia Muskan (2026) | Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health |
| Spermidine Cognition Meta-Analysis | Interventions that alter metabolite availability or metabolism, such as caloric restriction (CR) or reduced insulin/IGF‐1 signaling (IIS), extend lifespan across species (Gao et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Spermidine Cognition Meta-Analysis | This review highlights the role of endogenous metabolites in regulating longevity pathways and evaluates evidence across species to aid understanding metabolic regulation of aging and guiding future investigations. | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Spermidine Cognition Meta-Analysis | In UVB‐irradiated hairless mice, oral taurine preserved epidermal moisture and significantly reduced wrinkle formation, suggesting an anti‐photoaging action via its osmolyte and moisturizing roles (Yoshimura et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Spermidine Cognition Meta-Analysis | 2023 2018 2021 2025 2013 Aging is a multifactorial process driven by the interplay of genetic, environmental, and metabolic perturbations, with dysregulated nutrient sensing and metabolic dysfunction recognized as core hallmarks (Lopez‐Otin et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
Source documents