Saffron Sleep Meta-Analysis Evidence Table

Structured evidence table for Saffron Sleep Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Saffron Sleep Meta-AnalysisHowever, due to some potentially significant adverse events associated with its medicinal use at higher doses or prolonged administration, clinical monitoring should be considered.1Hasheminasab FS (2026)Adverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
Saffron Sleep Meta-AnalysisBackground Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications.1Hasheminasab FS (2026)Adverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
Saffron Sleep Meta-AnalysisThis systematic review aims to compile human data from studies on monopreparations of C.1Hasheminasab FS (2026)Adverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
Saffron Sleep Meta-AnalysisLevodopa remains the most effective therapy; however, it is associated with a wide range of side effects and shows little to no efficacy against non-motor symptoms.4Galla R (2026)Neuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.
Saffron Sleep Meta-AnalysisThe results demonstrated that the combined treatment (Mix) significantly restored cell viability after 6-OHDA exposure and more effectively reduced oxidative and nitrosative stress, as well as lipid peroxidation, compared to single compounds.4Galla R (2026)Neuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.
Saffron Sleep Meta-AnalysisIn conclusion, these results indicate that the Mix has a suggest a synergistic-like impact on various disease-causing pathways in PD, highlighting its promise as a multi-faceted neuroprotective approach.4Galla R (2026)Neuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.
Saffron Sleep Meta-AnalysisParkinson's disease (PD) is a neurodegenerative disorder characterised by dopamine deficiency and the accumulation of α-synuclein (α-syn), which aggregates into pathological inclusions known as Lewy bodies and Lewy neurites, distributed across multiple brain regions, with a particular prevalence in dopaminergic neurons.4Galla R (2026)Neuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.
topicSaffron Sleep Meta-Analysis
claimHowever, due to some potentially significant adverse events associated with its medicinal use at higher doses or prolonged administration, clinical monitoring should be considered.
evidence level1
citationHasheminasab FS (2026)
sourceAdverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
topicSaffron Sleep Meta-Analysis
claimBackground Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications.
evidence level1
citationHasheminasab FS (2026)
sourceAdverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
topicSaffron Sleep Meta-Analysis
claimThis systematic review aims to compile human data from studies on monopreparations of C.
evidence level1
citationHasheminasab FS (2026)
sourceAdverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
topicSaffron Sleep Meta-Analysis
claimLevodopa remains the most effective therapy; however, it is associated with a wide range of side effects and shows little to no efficacy against non-motor symptoms.
evidence level4
citationGalla R (2026)
sourceNeuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.
topicSaffron Sleep Meta-Analysis
claimThe results demonstrated that the combined treatment (Mix) significantly restored cell viability after 6-OHDA exposure and more effectively reduced oxidative and nitrosative stress, as well as lipid peroxidation, compared to single compounds.
evidence level4
citationGalla R (2026)
sourceNeuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.
topicSaffron Sleep Meta-Analysis
claimIn conclusion, these results indicate that the Mix has a suggest a synergistic-like impact on various disease-causing pathways in PD, highlighting its promise as a multi-faceted neuroprotective approach.
evidence level4
citationGalla R (2026)
sourceNeuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.
topicSaffron Sleep Meta-Analysis
claimParkinson's disease (PD) is a neurodegenerative disorder characterised by dopamine deficiency and the accumulation of α-synuclein (α-syn), which aggregates into pathological inclusions known as Lewy bodies and Lewy neurites, distributed across multiple brain regions, with a particular prevalence in dopaminergic neurons.
evidence level4
citationGalla R (2026)
sourceNeuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.

Source documents

  1. Adverse Events of Saffron (<i>Crocus sativus</i> L.): Systematic Review of Current Evidence.
  2. Neuroprotective Effects of the Combination of Green Tea, Saffron, Docosahexaenoic Acid, and α-Lipoic Acid in an In Vitro Model of Parkinson's Disease.