topicSaffron Mood Meta-Analysis
claimIt is often considered as one of the most intense experiences a woman may endure.Consequently, the fear of this pain contributes to an increased preference for cesarean delivery.It triggers increased fear and anxiety, which signals the sympathetic nervous system into a fight-or-flight response.
evidence level4
citationAlshdefat Aisha (2026)
sourceSaffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review
topicSaffron Mood Meta-Analysis
claim6 7 , Medical conditions associated with prolonged labor increase the maternal mortality rate, particularly in developing countries.
evidence level4
citationAlshdefat Aisha (2026)
sourceSaffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review
topicSaffron Mood Meta-Analysis
claim8 10 – 11 12 , Maternal healthcare demands reduced labor duration and pain severity.
evidence level4
citationAlshdefat Aisha (2026)
sourceSaffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review
topicSaffron Mood Meta-Analysis
claim4 5 However, this response suppresses the release of oxytocin, which impacts the labor process, often increasing its duration and subsequently adding more pain.Prolonged labor is also reported when fear and pain collectively lead to reactive pelvic floor muscle contraction.
evidence level4
citationAlshdefat Aisha (2026)
sourceSaffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review
topicSaffron Mood Meta-Analysis
claim1 2 Depression is a leading cause of disability worldwide and is characterised by sustained low mood, anhedonia, anergia, and a range of associated cognitive and somatic symptoms [].
evidence level4
citationMuacevic Alexander (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review
topicSaffron Mood Meta-Analysis
claimThis literature review summarises key randomised controlled trials (RCTs), meta-analyses, safety data, dosing patterns, and guideline positioning for saffron in depressive disorders, with emphasis on adult major depressive disorder (MDD) and related depressive symptomatology.
evidence level4
citationMuacevic Alexander (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review
topicSaffron Mood Meta-Analysis
claimMethods Crocus sativus' Databases and search strategy: A targeted search was undertaken in PubMed (primary database), with supplementary searching via Google Scholar and reference-list screening of key trials and evidence syntheses included in the bibliography.
evidence level4
citationMuacevic Alexander (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review
topicSaffron Mood Meta-Analysis
claimAlthough standard first-line approaches, such as lifestyle interventions, psychotherapy, and antidepressant medication, are effective for many patients, a meaningful minority experience partial response, intolerable adverse effects, or poor adherence [].
evidence level4
citationMuacevic Alexander (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review