topicRosemary Sleep Quality Randomized Trial
claimAcross studies, mobile interventions consistently improved user engagement, accessibility, and MH outcomes, including significant reductions in depression, anxiety, and stress symptoms ( p Conclusions mHealth applications substantially improve access to and delivery of MH services for AYPLHIV and related groups.
evidence level1
citationMuleya C (2026)
sourceMobile health applications for enhancing mental health access and outcomes among adolescents and young people living with HIV: a systematic review.
topicRosemary Sleep Quality Randomized Trial
claimBackground Mental health (MH) disorders remain a major global public health concern, disproportionately affecting adolescents and young people living with HIV (AYPLHIV).
evidence level1
citationMuleya C (2026)
sourceMobile health applications for enhancing mental health access and outcomes among adolescents and young people living with HIV: a systematic review.
topicRosemary Sleep Quality Randomized Trial
claimLimited access to MH services, stigma, and a shortage of trained professionals hinder effective care, particularly in low-resource settings.
evidence level1
citationMuleya C (2026)
sourceMobile health applications for enhancing mental health access and outcomes among adolescents and young people living with HIV: a systematic review.
topicRosemary Sleep Quality Randomized Trial
claimHowever, traditional sedative-hypnotic medications such as benzodiazepines, while effective, are often associated with dependency and adverse effects (;;).
evidence level3
citationMa Dongchuan (2026)
sourceMulti-target regulatory mechanisms and clinical assessment of natural products for insomnia: a review
topicRosemary Sleep Quality Randomized Trial
claimFrost et al., 2024 In summary, the prevalence of insomnia and its health implications prompt a reevaluation of the limitations associated with conventional pharmacotherapy.
evidence level3
citationMa Dongchuan (2026)
sourceMulti-target regulatory mechanisms and clinical assessment of natural products for insomnia: a review
topicRosemary Sleep Quality Randomized Trial
claimNotably, chronic insomnia is characterized by reduced GABA A receptor sensitivity in the anterior hypothalamus alongside elevated orexinergic activity in the lateral hypothalamus.
evidence level3
citationMa Dongchuan (2026)
sourceMulti-target regulatory mechanisms and clinical assessment of natural products for insomnia: a review
topicRosemary Sleep Quality Randomized Trial
claimSutton, 2021 Manolis et al., 2021 Park et al., 2023 Insomnia is a prevalent sleep disorder characterized by difficulty initiating sleep, sleep maintenance difficulties, and early morning awakening, often accompanied by impaired daytime functioning.
evidence level3
citationMa Dongchuan (2026)
sourceMulti-target regulatory mechanisms and clinical assessment of natural products for insomnia: a review