topicProbiotic Mood Meta-Analysis
claimThis review adopts a systems-level perspective to synthesize emerging evidence on probiotic-driven gut–brain, gut–skin, gut–oral, and metabolic interactions, emphasizing shared mechanisms rather than isolated clinical outcomes.
evidence level3
citationZalila-Kolsi Imen (2026)
sourceProbiotics and the Human Microbiome: Classical Functions, Emerging Systemic Roles, and Future Therapeutic Frontiers
topicProbiotic Mood Meta-Analysis
claimIn parallel, advances in encapsulation and delivery technologies have improved probiotic survival during gastrointestinal transit, thereby enhancing their functional efficacy within the gut.
evidence level3
citationZalila-Kolsi Imen (2026)
sourceProbiotics and the Human Microbiome: Classical Functions, Emerging Systemic Roles, and Future Therapeutic Frontiers
topicProbiotic Mood Meta-Analysis
claimrhamnosus 14 16 Functionally, experimental and clinical studies indicate that strain-specificspecies, such as,, and, regulate gut motility and carbohydrate metabolism, contributing to improved lactose digestion and alleviation of constipation and bloating [].
evidence level3
citationZalila-Kolsi Imen (2026)
sourceProbiotics and the Human Microbiome: Classical Functions, Emerging Systemic Roles, and Future Therapeutic Frontiers
topicProbiotic Mood Meta-Analysis
claim1 2 3 4 5 Lactobacillus Bifidobacterium Enterococcus Streptococcus Saccharomyces boulardii, The term “probiotics,” which comes from the Greek word “for life,” refers to live microorganisms that, when given in sufficient quantities, promote the host’s health [].
evidence level3
citationZalila-Kolsi Imen (2026)
sourceProbiotics and the Human Microbiome: Classical Functions, Emerging Systemic Roles, and Future Therapeutic Frontiers
topicProbiotic Mood Meta-Analysis
claimA comprehensive review of psychiatric presentations reported that psychiatric symptoms span attention problems, anxiety, mood/behavioral disorders, and psychosis and identified > 100 IEMs associated with psychiatric manifestations; in a curated analysis, 94 IEMs were linked to psychiatric symptoms, with mood changes ranging from depressive syndromes to bipolar-like presentations [].
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicProbiotic Mood Meta-Analysis
claim6 7 Clinically, mood disorders associated with IEMs often exhibit characteristic diagnostic patterns that may aid early recognition.
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicProbiotic Mood Meta-Analysis
claimWhen methylation capacity is constrained, through low folate/B12 status, reduced enzyme function (e.g., MTHFR variants), inflammation, oxidative stress, alcohol use, or high metabolic demand, homocysteine can rise, and SAMe availability can fall, creating a low methylation status that plausibly amplifies emotional volatility via neurotransmitter and epigenetic pathways [].
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicProbiotic Mood Meta-Analysis
claim1 2 Depression and anxiety disorders are leading contributors to global disability.
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression