evidence table

Prebiotic Sleep Meta-Analysis Evidence Table

Structured evidence table for Prebiotic Sleep Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Prebiotic Sleep Meta-AnalysisPreclinical research, primarily in experimental animal models, has demonstrated a causal link between microbiota composition and developmental processes such as myelination, synaptic plasticity, and socio-emotional behaviors, whereas human evidence remains largely associative and heterogeneous.1Carnazzo SM (2026)Early-Life Microbiota Modulation and Neurodevelopment in Infants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Prebiotic Sleep Meta-AnalysisChanges in microbial composition during early infancy by various factors (mode of delivery, nutritional practices, antibiotic usage, and environmental influences) have been correlated with observable variances in cognitive abilities, temperament, stress response, and the predisposition to neurodevelopmental disorders.1Carnazzo SM (2026)Early-Life Microbiota Modulation and Neurodevelopment in Infants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Prebiotic Sleep Meta-AnalysisConsequently, microbiota-targeted interventions such as probiotics, prebiotics, and synbiotics are being explored as avenues to enrich beneficial microbial taxa, enhance short-chain fatty acid production, fortify mucosal immunity, and mitigate inflammatory responses during these critical periods.1Carnazzo SM (2026)Early-Life Microbiota Modulation and Neurodevelopment in Infants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Prebiotic Sleep Meta-AnalysisBACKGROUND: With the growing recognition of the limitations associated with conventional treatments for anxiety and depression, there has been increasing interest in alternative and adjunct therapies, particularly probiotics, prebiotics, and synbiotics.1Zhang J (2025)The efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.
Prebiotic Sleep Meta-AnalysisThe Cochrane risk of bias tool was used to evaluate the quality of the included studies.1Zhang J (2025)The efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.
Prebiotic Sleep Meta-AnalysisCONCLUSION: These findings suggest that probiotics, prebiotics, and synbiotics offer promising adjunctive treatments for anxiety, depression, and sleep disturbances.1Zhang J (2025)The efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.
Prebiotic Sleep Meta-AnalysisHowever, current research results regarding their efficacy in treating anxiety, depression, and sleep have been inconsistent.1Zhang J (2025)The efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.
topicPrebiotic Sleep Meta-Analysis
claimPreclinical research, primarily in experimental animal models, has demonstrated a causal link between microbiota composition and developmental processes such as myelination, synaptic plasticity, and socio-emotional behaviors, whereas human evidence remains largely associative and heterogeneous.
evidence level1
citationCarnazzo SM (2026)
sourceEarly-Life Microbiota Modulation and Neurodevelopment in Infants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicPrebiotic Sleep Meta-Analysis
claimChanges in microbial composition during early infancy by various factors (mode of delivery, nutritional practices, antibiotic usage, and environmental influences) have been correlated with observable variances in cognitive abilities, temperament, stress response, and the predisposition to neurodevelopmental disorders.
evidence level1
citationCarnazzo SM (2026)
sourceEarly-Life Microbiota Modulation and Neurodevelopment in Infants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicPrebiotic Sleep Meta-Analysis
claimConsequently, microbiota-targeted interventions such as probiotics, prebiotics, and synbiotics are being explored as avenues to enrich beneficial microbial taxa, enhance short-chain fatty acid production, fortify mucosal immunity, and mitigate inflammatory responses during these critical periods.
evidence level1
citationCarnazzo SM (2026)
sourceEarly-Life Microbiota Modulation and Neurodevelopment in Infants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
topicPrebiotic Sleep Meta-Analysis
claimBACKGROUND: With the growing recognition of the limitations associated with conventional treatments for anxiety and depression, there has been increasing interest in alternative and adjunct therapies, particularly probiotics, prebiotics, and synbiotics.
evidence level1
citationZhang J (2025)
sourceThe efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.
topicPrebiotic Sleep Meta-Analysis
claimThe Cochrane risk of bias tool was used to evaluate the quality of the included studies.
evidence level1
citationZhang J (2025)
sourceThe efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.
topicPrebiotic Sleep Meta-Analysis
claimCONCLUSION: These findings suggest that probiotics, prebiotics, and synbiotics offer promising adjunctive treatments for anxiety, depression, and sleep disturbances.
evidence level1
citationZhang J (2025)
sourceThe efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.
topicPrebiotic Sleep Meta-Analysis
claimHowever, current research results regarding their efficacy in treating anxiety, depression, and sleep have been inconsistent.
evidence level1
citationZhang J (2025)
sourceThe efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.

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Source documents

  1. Early-Life Microbiota Modulation and Neurodevelopment in Infants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
  2. The efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.