topicPhosphatidylserine Sleep Latency Randomized Trial
claimAdditionally, the decline in magnesium concentrations in modern food crops may contribute to reduced dietary magnesium intake, potentially increasing the risk of magnesium deficiency and chronic health conditions, such as cardiovascular disease and metabolic syndrome ().
evidence level2
citationLopresti Adrian L. (2026)
sourceThe effects of magnesium L-threonate (Magtein ® ) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial
topicPhosphatidylserine Sleep Latency Randomized Trial
claimMoreover, lower blood concentrations of magnesium have been identified in adults with reduced cognitive performance, mild cognitive impairment, and Alzheimer’s disease ().
evidence level2
citationLopresti Adrian L. (2026)
sourceThe effects of magnesium L-threonate (Magtein ® ) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial
topicPhosphatidylserine Sleep Latency Randomized Trial
claimHowever, it is important to note that these correlational studies do not confirm causality, as these health conditions are associated with several factors that may influence magnesium status, such as poorer dietary habits or gastrointestinal changes that affect magnesium absorption (,).
evidence level2
citationLopresti Adrian L. (2026)
sourceThe effects of magnesium L-threonate (Magtein ® ) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial
topicPhosphatidylserine Sleep Latency Randomized Trial
claimIt is required as a cofactor in more than 300 enzymatic reactions that are important for energy generation, cardiovascular health, neuromuscular function, bone and teeth maintenance, cognition, and nervous system function (,).
evidence level2
citationLopresti Adrian L. (2026)
sourceThe effects of magnesium L-threonate (Magtein ® ) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial
topicPhosphatidylserine Sleep Latency Randomized Trial
claimSleep is a complex biological process whose evolutionary purpose has remained equivocal for quite some time.More recently, however, compelling evidence has emerged, leading to recognition of the numerous metabolic and physiological functions sleep contributes to and actively supports.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicPhosphatidylserine Sleep Latency Randomized Trial
claimEpidemiological studies have revealed that sleep deprivation is associated with an increased risk of all-cause mortality,alongside numerous chronic conditions imposing a heavy burden on our healthcare and socioeconomic systems alike,including cardiovascular disease, stroke, obesity, type 2 diabetes, and various types of cancer and neurological disorders.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicPhosphatidylserine Sleep Latency Randomized Trial
claimThe scope of this narrative review is to summarize the available evidence on the mechanisms of action and potential benefits of the above-listed nutrients in the context of acute or chronic sleep disturbances.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicPhosphatidylserine Sleep Latency Randomized Trial
claim, , Over the past few decades, there has been an increasing appreciation of the negative impact of sleep disturbances and circadian misalignments on all aspects of human health and performance, ranging from objective alertness, learning, memory, and cognition to emotional regulation, social wellbeing and, most remarkably, physical health.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review