evidence table

Omega-3 Mood Meta-Analysis Evidence Table

Structured evidence table for Omega-3 Mood Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Omega-3 Mood Meta-AnalysisA comprehensive review of psychiatric presentations reported that psychiatric symptoms span attention problems, anxiety, mood/behavioral disorders, and psychosis and identified > 100 IEMs associated with psychiatric manifestations; in a curated analysis, 94 IEMs were linked to psychiatric symptoms, with mood changes ranging from depressive syndromes to bipolar-like presentations [].3Hachmeriyan Antoniya (2026)From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
Omega-3 Mood Meta-Analysis6 7 Clinically, mood disorders associated with IEMs often exhibit characteristic diagnostic patterns that may aid early recognition.3Hachmeriyan Antoniya (2026)From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
Omega-3 Mood Meta-AnalysisWhen methylation capacity is constrained, through low folate/B12 status, reduced enzyme function (e.g., MTHFR variants), inflammation, oxidative stress, alcohol use, or high metabolic demand, homocysteine can rise, and SAMe availability can fall, creating a low methylation status that plausibly amplifies emotional volatility via neurotransmitter and epigenetic pathways [].3Hachmeriyan Antoniya (2026)From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
Omega-3 Mood Meta-Analysis1 2 Depression and anxiety disorders are leading contributors to global disability.3Hachmeriyan Antoniya (2026)From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
Omega-3 Mood Meta-Analysis9 10 Given the modest efficacy of standard interventions, interest in well-tolerated, low-risk alternatives is increasing ().3Fleig Katharina (2026)Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential
Omega-3 Mood Meta-AnalysisConversely, omega-3 PUFAs eicosapentaenoic acid (EPA; 20:5ω3), docosapentaenoic acid (DPA; 22:5ω3), and docosahexaenoic acid (DHA; 22:6ω3) are predominantly found in fatty marine fish and algae (,).3Fleig Katharina (2026)Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential
Omega-3 Mood Meta-AnalysisEvidence suggests that ALA may have a neuroprotective and anti-inflammatory potential concerning systemic, neuroinflammatory, and mental disorders ().3Fleig Katharina (2026)Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential
Omega-3 Mood Meta-Analysis1 2 3 5 5 Mental disorders currently rank among the leading contributors to the global burden of disease, posing substantial individual and societal challenges (,).3Fleig Katharina (2026)Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential
topicOmega-3 Mood Meta-Analysis
claimA comprehensive review of psychiatric presentations reported that psychiatric symptoms span attention problems, anxiety, mood/behavioral disorders, and psychosis and identified > 100 IEMs associated with psychiatric manifestations; in a curated analysis, 94 IEMs were linked to psychiatric symptoms, with mood changes ranging from depressive syndromes to bipolar-like presentations [].
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicOmega-3 Mood Meta-Analysis
claim6 7 Clinically, mood disorders associated with IEMs often exhibit characteristic diagnostic patterns that may aid early recognition.
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicOmega-3 Mood Meta-Analysis
claimWhen methylation capacity is constrained, through low folate/B12 status, reduced enzyme function (e.g., MTHFR variants), inflammation, oxidative stress, alcohol use, or high metabolic demand, homocysteine can rise, and SAMe availability can fall, creating a low methylation status that plausibly amplifies emotional volatility via neurotransmitter and epigenetic pathways [].
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicOmega-3 Mood Meta-Analysis
claim1 2 Depression and anxiety disorders are leading contributors to global disability.
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicOmega-3 Mood Meta-Analysis
claim9 10 Given the modest efficacy of standard interventions, interest in well-tolerated, low-risk alternatives is increasing ().
evidence level3
citationFleig Katharina (2026)
sourceOmega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential
topicOmega-3 Mood Meta-Analysis
claimConversely, omega-3 PUFAs eicosapentaenoic acid (EPA; 20:5ω3), docosapentaenoic acid (DPA; 22:5ω3), and docosahexaenoic acid (DHA; 22:6ω3) are predominantly found in fatty marine fish and algae (,).
evidence level3
citationFleig Katharina (2026)
sourceOmega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential
topicOmega-3 Mood Meta-Analysis
claimEvidence suggests that ALA may have a neuroprotective and anti-inflammatory potential concerning systemic, neuroinflammatory, and mental disorders ().
evidence level3
citationFleig Katharina (2026)
sourceOmega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential
topicOmega-3 Mood Meta-Analysis
claim1 2 3 5 5 Mental disorders currently rank among the leading contributors to the global burden of disease, posing substantial individual and societal challenges (,).
evidence level3
citationFleig Katharina (2026)
sourceOmega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential

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Source documents

  1. From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
  2. Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential