evidence table
Omega-3 Mood Meta-Analysis Evidence Table
Structured evidence table for Omega-3 Mood Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Omega-3 Mood Meta-Analysis | A comprehensive review of psychiatric presentations reported that psychiatric symptoms span attention problems, anxiety, mood/behavioral disorders, and psychosis and identified > 100 IEMs associated with psychiatric manifestations; in a curated analysis, 94 IEMs were linked to psychiatric symptoms, with mood changes ranging from depressive syndromes to bipolar-like presentations []. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Omega-3 Mood Meta-Analysis | 6 7 Clinically, mood disorders associated with IEMs often exhibit characteristic diagnostic patterns that may aid early recognition. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Omega-3 Mood Meta-Analysis | When methylation capacity is constrained, through low folate/B12 status, reduced enzyme function (e.g., MTHFR variants), inflammation, oxidative stress, alcohol use, or high metabolic demand, homocysteine can rise, and SAMe availability can fall, creating a low methylation status that plausibly amplifies emotional volatility via neurotransmitter and epigenetic pathways []. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Omega-3 Mood Meta-Analysis | 1 2 Depression and anxiety disorders are leading contributors to global disability. | 3 | Hachmeriyan Antoniya (2026) | From Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression |
| Omega-3 Mood Meta-Analysis | 9 10 Given the modest efficacy of standard interventions, interest in well-tolerated, low-risk alternatives is increasing (). | 3 | Fleig Katharina (2026) | Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential |
| Omega-3 Mood Meta-Analysis | Conversely, omega-3 PUFAs eicosapentaenoic acid (EPA; 20:5ω3), docosapentaenoic acid (DPA; 22:5ω3), and docosahexaenoic acid (DHA; 22:6ω3) are predominantly found in fatty marine fish and algae (,). | 3 | Fleig Katharina (2026) | Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential |
| Omega-3 Mood Meta-Analysis | Evidence suggests that ALA may have a neuroprotective and anti-inflammatory potential concerning systemic, neuroinflammatory, and mental disorders (). | 3 | Fleig Katharina (2026) | Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential |
| Omega-3 Mood Meta-Analysis | 1 2 3 5 5 Mental disorders currently rank among the leading contributors to the global burden of disease, posing substantial individual and societal challenges (,). | 3 | Fleig Katharina (2026) | Omega-3 fatty acids in mental disorders: from neurobiological and metabolic mechanisms to therapeutic potential |
Source documents