topicNicotinamide Riboside Exercise Performance Randomized Trial
claimThis review summarizes current evidence on nutritional compounds that target aging-related pathways, focusing on interventions that influence mitochondrial health, cognitive performance, immune function, metabolic regulation, and maintenance of muscle mass in older adults.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicNicotinamide Riboside Exercise Performance Randomized Trial
claimRecent findings Evidence indicates that several targeted nutrients, including protein, probiotics, antioxidants, and emerging mitochondrial-support compounds, may contribute to healthy aging.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicNicotinamide Riboside Exercise Performance Randomized Trial
claimA personalized, evidence-informed supplementation strategy integrated with exercise and balanced nutrition may help optimize physiological function in aging adults.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicNicotinamide Riboside Exercise Performance Randomized Trial
claimPurpose of review Aging is marked by progressive physiological decline driven by chronic inflammation, mitochondrial dysfunction, and impaired metabolic and musculoskeletal resilience.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicNicotinamide Riboside Exercise Performance Randomized Trial
claimSarcopenia is a progressive and multifactorial muscle disorder associated with diminished strength, reduced functional capacity, and increased risk of adverse health outcomes including frailty, falls, and mortality.
evidence level4
citationChin HS (2026)
sourceMolecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review.
topicNicotinamide Riboside Exercise Performance Randomized Trial
claimThis review examines emerging evidence linking anabolic resistance, mitochondrial dysfunction, neuromuscular instability, and chronic inflammation to impaired regeneration and disrupted proteostasis.
evidence level4
citationChin HS (2026)
sourceMolecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review.
topicNicotinamide Riboside Exercise Performance Randomized Trial
claimAlthough exercise remains the cornerstone therapy, its benefits are often constrained in patients with multimorbidity or reduced mobility.
evidence level4
citationChin HS (2026)
sourceMolecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review.
topicNicotinamide Riboside Exercise Performance Randomized Trial
claimDespite its clinical burden, the molecular pathogenesis of sarcopenia remains poorly understood, which hinders the development of precise therapeutic strategies.
evidence level4
citationChin HS (2026)
sourceMolecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review.