topicMagnesium Threonate Sleep Quality Randomized Trial
claimResults Compared to the placebo, Magtein ® was associated with greater improvements in overall cognitive performance as measured by the NIH Total Cognition Composite ( p = 0.043), with larger treatment effects on working and episodic memory.
evidence level2
citationLopresti AL (2026)
sourceThe effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
topicMagnesium Threonate Sleep Quality Randomized Trial
claimBased on data from the sleep tracking ring, there were no group differences in sleep outcomes, although there was a greater reduction in HR ( p = 0.030) and an increase in HRV ( p = 0.036), a physiological marker of stress reduction and improved autonomic balance.
evidence level2
citationLopresti AL (2026)
sourceThe effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
topicMagnesium Threonate Sleep Quality Randomized Trial
claimConclusion The results from this study suggest Magtein ® supplementation for 6 weeks improves overall cognition, cognitive age, working memory, reaction time, HR, HRV, and some subjective, but not objective measures of sleep in healthy adults with self-reported dissatisfied sleep.
evidence level2
citationLopresti AL (2026)
sourceThe effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
topicMagnesium Threonate Sleep Quality Randomized Trial
claimThe purpose of this two-arm, 6-week, parallel-group, randomised, double-blind, placebo-controlled trial was to examine the effects of magnesium L-threonate (Magtein ® ) supplementation on cognitive performance, cognitive age, sleep quality, and selected physiological indicators in adults.
evidence level2
citationLopresti AL (2026)
sourceThe effects of magnesium L-threonate (Magtein<sup>®</sup>) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
topicMagnesium Threonate Sleep Quality Randomized Trial
claimFailure to meet the recommended 7-9 hours of restful sleep per night is known to increase the risk of several health conditions, reason why regular and adequate sleep should be seen as a priority instead of an unnecessary commodity easily traded as required by the commitments of our busy lives.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicMagnesium Threonate Sleep Quality Randomized Trial
claimWhile both the quantity and the quality of sleep can be largely improved with relatively straightforward practices dictated by good sleep hygiene, emerging research suggests that dietary and supplementation protocols focused on certain foods, nutrients, and biochemical compounds with sleep-promoting properties can act as subsidiary sleep aids in complementing these behavioral changes.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicMagnesium Threonate Sleep Quality Randomized Trial
claimThe scope of this narrative review is to summarize the available evidence on the potential benefits of selected nutraceuticals in the context of circadian rhythm and sleep disturbances, namely melatonin, magnesium, omega-3 fatty acids, tart cherry juice, kiwifruit, apigenin, valerian root, L-theanine, glycine, ashwagandha, myoinositol, Rhodiola rosea, and phosphatidylserine.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicMagnesium Threonate Sleep Quality Randomized Trial
claimHumans spend approximately one third of their life asleep but, as counterintuitive as it may sound, sleep is far from being a quiet state of inactivity.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.