evidence table

Magnesium Glycinate Muscle Cramps Randomized Trial Evidence Table

Name: Magnesium Glycinate Muscle Cramps Randomized Trial Evidence Table
Creator: Migaku
License: https://creativecommons.org/licenses/by/4.0/

Structured evidence table for Magnesium Glycinate Muscle Cramps Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Magnesium Glycinate Muscle Cramps Randomized Trial	Temporomandibular disorders (TMDs) are among the most common causes of chronic orofacial pain, with myalgia of the masticatory muscles being a major.Patients frequently present with persistent aching pain, muscle tenderness, and restricted jaw function, all of which significantly impair quality of life.While existing treatments are mainly symptomatic,emerging evidence suggests a role for electrolyte modulation.	1	Patil Shankargouda (2026)	The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Magnesium Glycinate Muscle Cramps Randomized Trial	Notably, a recent randomized controlled trial demonstrated that local magnesium sulphate injection into the masseter muscle significantly reduced pain intensity and improved function in TMD myalgia, providing a direct clinical link between electrolyte biology and orofacial pain.This observation highlights the potential for broader exploration of electrolyte-based interventions in TMD.	1	Patil Shankargouda (2026)	The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Magnesium Glycinate Muscle Cramps Randomized Trial	Muscle cramps – whether idiopathic nocturnal, pregnancy-associated, or exercise-induced – arise from abnormal neuromuscular excitability,impaired ion-channel regulation,and nociceptor sensitization.These same processes are also implicated in TMD myalgia,suggesting that insights from cramp interventions may inform novel strategies for managing orofacial muscle pain.	1	Patil Shankargouda (2026)	The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder
Magnesium Glycinate Muscle Cramps Randomized Trial	Accumulating evidence indicates that magnesium regulates bone metabolism through multiple signaling pathways, including PI3K/Akt, OPG/RANKL/RANK, TRPM, etc.	3	Sheng Shaoying (2026)	Application and translational research of magnesium in nursing care of orthopedic diseases: from mechanism to clinical translation
Magnesium Glycinate Muscle Cramps Randomized Trial	Dysregulated magnesium metabolism has been associated with osteoporosis, impaired fracture healing, and other skeletal disorders ().	3	Sheng Shaoying (2026)	Application and translational research of magnesium in nursing care of orthopedic diseases: from mechanism to clinical translation
Magnesium Glycinate Muscle Cramps Randomized Trial	A central graphic links magnesium to its effects: pathologies and therapeutics, biomaterials applications with biodegradable magnesium implants promoting bone regeneration, and clinical or nursing applications such as supplementation, improved bone health, postoperative care, and pain management.	3	Sheng Shaoying (2026)	Application and translational research of magnesium in nursing care of orthopedic diseases: from mechanism to clinical translation
Magnesium Glycinate Muscle Cramps Randomized Trial	Jallot, et al., 2005 Xia, et al., 2025 Magnesium is the fourth most abundant cation in human body and plays a crucial role in maintaining physiological homeostasis.	3	Sheng Shaoying (2026)	Application and translational research of magnesium in nursing care of orthopedic diseases: from mechanism to clinical translation