topicMagnesium Anxiety Meta-Analysis
claimA comprehensive review of psychiatric presentations reported that psychiatric symptoms span attention problems, anxiety, mood/behavioral disorders, and psychosis and identified > 100 IEMs associated with psychiatric manifestations; in a curated analysis, 94 IEMs were linked to psychiatric symptoms, with mood changes ranging from depressive syndromes to bipolar-like presentations [].
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicMagnesium Anxiety Meta-Analysis
claim6 7 Clinically, mood disorders associated with IEMs often exhibit characteristic diagnostic patterns that may aid early recognition.
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicMagnesium Anxiety Meta-Analysis
claimWhen methylation capacity is constrained, through low folate/B12 status, reduced enzyme function (e.g., MTHFR variants), inflammation, oxidative stress, alcohol use, or high metabolic demand, homocysteine can rise, and SAMe availability can fall, creating a low methylation status that plausibly amplifies emotional volatility via neurotransmitter and epigenetic pathways [].
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicMagnesium Anxiety Meta-Analysis
claim1 2 Depression and anxiety disorders are leading contributors to global disability.
evidence level3
citationHachmeriyan Antoniya (2026)
sourceFrom Plate to Mind: Scientific Perspectives on Foods That May Influence Anxiety and Depression
topicMagnesium Anxiety Meta-Analysis
claimThus, this review aims to integrate advances in magnesium physiology with contemporary clinical and nutritional evidence, providing a consolidated strategy for understanding the causes, manifestations, diagnosis, and management of hypomagnesemia.
evidence level3
citationPapagiannidou Anastasia (2026)
sourceHypomagnesemia: A Clinical and Nutritional Update
topicMagnesium Anxiety Meta-Analysis
claimFinally, we also cover practical laboratory assessment and evidence-informed repletion strategies.
evidence level3
citationPapagiannidou Anastasia (2026)
sourceHypomagnesemia: A Clinical and Nutritional Update
topicMagnesium Anxiety Meta-Analysis
claimFinally, we recognize that the literature on magnesium physiology and hypomagnesemia is extensive, and although we aimed to incorporate the most relevant and high-quality evidence, not all available studies could be discussed in detail within this review.
evidence level3
citationPapagiannidou Anastasia (2026)
sourceHypomagnesemia: A Clinical and Nutritional Update
topicMagnesium Anxiety Meta-Analysis
claim2+ ++ + + 2+ ++ 1 Magnesium (Mg or Mg, Mg), described previously as the “forgotten electrolyte”, is a fundamental element for living organisms being the fourth most abundant mineral in the human body, following sodium (Na or Na), potassium (K or K) and calcium (Ca or Ca, Ca), and the second most abundant cation in the intracellular fluid after potassium [].
evidence level3
citationPapagiannidou Anastasia (2026)
sourceHypomagnesemia: A Clinical and Nutritional Update