topicLion'S Mane Memory Meta-Analysis
claimTo address the risk of quality bias, the ROBIS tool was used to eliminate bias and ensure the quality of the included studies.
evidence level1
citationMenon A (2025)
sourceBenefits, side effects, and uses of <i>Hericium erinaceus</i> as a supplement: a systematic review.
topicLion'S Mane Memory Meta-Analysis
claimResult This review includes results from five randomized controlled trials (RCTs), 15 laboratory studies, three pilot clinical trials (PCTs), one cohort study, one case report, and one computer analysis.
evidence level1
citationMenon A (2025)
sourceBenefits, side effects, and uses of <i>Hericium erinaceus</i> as a supplement: a systematic review.
topicLion'S Mane Memory Meta-Analysis
claimIn vitro laboratory studies on cancer and cell apoptosis, focusing on leukemia and gastric cancer cells, found that isolated erinacine A from the mycelium of HE inhibited the invasiveness of MKN28 and TSGH 9201 cells and activated caspase pathways.
evidence level1
citationMenon A (2025)
sourceBenefits, side effects, and uses of <i>Hericium erinaceus</i> as a supplement: a systematic review.
topicLion'S Mane Memory Meta-Analysis
claimIntroduction Hericium erinaceus (HE), commonly known as the Lion's Mane mushroom, is an edible, medicinal fungus containing bioactive polysaccharides.
evidence level1
citationMenon A (2025)
sourceBenefits, side effects, and uses of <i>Hericium erinaceus</i> as a supplement: a systematic review.
topicLion'S Mane Memory Meta-Analysis
claimFigure 1 Thus, in the present review we aimed to summarize the preclinical and clinical evidence of selected nutraceuticals, focusing on biotin, flavonoids especially luteolin, folic acid, Huperzine A, Lion’s mane, olive oil polyphenols (oleuropein and hydroxytyrosol [HT]), and palmitoylethanolamide (PEA).
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Memory Meta-Analysis
claimThe present narrative review highlights current mechanistic insights, as well as evidence from experimental and clinical studies regarding their potential roles in supporting cognitive function, modulating neuroinflammation, and mitigating neurodegenerative processes.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Memory Meta-Analysis
claimIt should be noted that the present work consists of a review and not a dosing guideline.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Memory Meta-Analysis
claim1 1 Brain health is a multidimensional and evolving concept that is difficult to evaluate and quantify [].
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience