topicLion'S Mane Cognition Meta-Analysis
claim3 4 5 Lion’s mane mushroom contains multiple phytochemicals, such as-glucan and hericenones, which promote NGF synthesisErinacines have also been found to prevent neuronal death, promote neurite outgrowth, and support the maintenance of neuronal functions ().
evidence level1
citationMenon Arya (2025)
sourceBenefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
topicLion'S Mane Cognition Meta-Analysis
claimMicrosoft Excel was used to extract data from the selected studies and to assess the risk of bias.
evidence level1
citationMenon Arya (2025)
sourceBenefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
topicLion'S Mane Cognition Meta-Analysis
claim12 16 The Cochrane RoB-2, ROBINS-I, Newcastle-Ottawa Scale (NOS), IHE Case Report Quality Appraisal Tool, and SYRCLE Risk of Bias tool identified concerns regarding the study’s eligibility criteria (–).
evidence level1
citationMenon Arya (2025)
sourceBenefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
topicLion'S Mane Cognition Meta-Analysis
claimHericium erinaceus 1 2 (HE) is a popular and traditional edible mushroom native to North America, Europe, and Asia.
evidence level1
citationMenon Arya (2025)
sourceBenefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
topicLion'S Mane Cognition Meta-Analysis
claimFigure 1 Thus, in the present review we aimed to summarize the preclinical and clinical evidence of selected nutraceuticals, focusing on biotin, flavonoids especially luteolin, folic acid, Huperzine A, Lion’s mane, olive oil polyphenols (oleuropein and hydroxytyrosol [HT]), and palmitoylethanolamide (PEA).
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Meta-Analysis
claimThe present narrative review highlights current mechanistic insights, as well as evidence from experimental and clinical studies regarding their potential roles in supporting cognitive function, modulating neuroinflammation, and mitigating neurodegenerative processes.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Meta-Analysis
claimIt should be noted that the present work consists of a review and not a dosing guideline.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Meta-Analysis
claim1 1 Brain health is a multidimensional and evolving concept that is difficult to evaluate and quantify [].
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience