Lion'S Mane Cognition Meta-Analysis Evidence Table

Structured evidence table for Lion'S Mane Cognition Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Lion'S Mane Cognition Meta-Analysis3 4 5 Lion’s mane mushroom contains multiple phytochemicals, such as-glucan and hericenones, which promote NGF synthesisErinacines have also been found to prevent neuronal death, promote neurite outgrowth, and support the maintenance of neuronal functions ().1Menon Arya (2025)Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
Lion'S Mane Cognition Meta-AnalysisMicrosoft Excel was used to extract data from the selected studies and to assess the risk of bias.1Menon Arya (2025)Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
Lion'S Mane Cognition Meta-Analysis12 16 The Cochrane RoB-2, ROBINS-I, Newcastle-Ottawa Scale (NOS), IHE Case Report Quality Appraisal Tool, and SYRCLE Risk of Bias tool identified concerns regarding the study’s eligibility criteria (–).1Menon Arya (2025)Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
Lion'S Mane Cognition Meta-AnalysisHericium erinaceus 1 2 (HE) is a popular and traditional edible mushroom native to North America, Europe, and Asia.1Menon Arya (2025)Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
Lion'S Mane Cognition Meta-AnalysisFigure 1 Thus, in the present review we aimed to summarize the preclinical and clinical evidence of selected nutraceuticals, focusing on biotin, flavonoids especially luteolin, folic acid, Huperzine A, Lion’s mane, olive oil polyphenols (oleuropein and hydroxytyrosol [HT]), and palmitoylethanolamide (PEA).3Venetsanaki Vasiliki (2026)Natural Molecules for Brain Health and Resilience
Lion'S Mane Cognition Meta-AnalysisThe present narrative review highlights current mechanistic insights, as well as evidence from experimental and clinical studies regarding their potential roles in supporting cognitive function, modulating neuroinflammation, and mitigating neurodegenerative processes.3Venetsanaki Vasiliki (2026)Natural Molecules for Brain Health and Resilience
Lion'S Mane Cognition Meta-AnalysisIt should be noted that the present work consists of a review and not a dosing guideline.3Venetsanaki Vasiliki (2026)Natural Molecules for Brain Health and Resilience
Lion'S Mane Cognition Meta-Analysis1 1 Brain health is a multidimensional and evolving concept that is difficult to evaluate and quantify [].3Venetsanaki Vasiliki (2026)Natural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Meta-Analysis
claim3 4 5 Lion’s mane mushroom contains multiple phytochemicals, such as-glucan and hericenones, which promote NGF synthesisErinacines have also been found to prevent neuronal death, promote neurite outgrowth, and support the maintenance of neuronal functions ().
evidence level1
citationMenon Arya (2025)
sourceBenefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
topicLion'S Mane Cognition Meta-Analysis
claimMicrosoft Excel was used to extract data from the selected studies and to assess the risk of bias.
evidence level1
citationMenon Arya (2025)
sourceBenefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
topicLion'S Mane Cognition Meta-Analysis
claim12 16 The Cochrane RoB-2, ROBINS-I, Newcastle-Ottawa Scale (NOS), IHE Case Report Quality Appraisal Tool, and SYRCLE Risk of Bias tool identified concerns regarding the study’s eligibility criteria (–).
evidence level1
citationMenon Arya (2025)
sourceBenefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
topicLion'S Mane Cognition Meta-Analysis
claimHericium erinaceus 1 2 (HE) is a popular and traditional edible mushroom native to North America, Europe, and Asia.
evidence level1
citationMenon Arya (2025)
sourceBenefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
topicLion'S Mane Cognition Meta-Analysis
claimFigure 1 Thus, in the present review we aimed to summarize the preclinical and clinical evidence of selected nutraceuticals, focusing on biotin, flavonoids especially luteolin, folic acid, Huperzine A, Lion’s mane, olive oil polyphenols (oleuropein and hydroxytyrosol [HT]), and palmitoylethanolamide (PEA).
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Meta-Analysis
claimThe present narrative review highlights current mechanistic insights, as well as evidence from experimental and clinical studies regarding their potential roles in supporting cognitive function, modulating neuroinflammation, and mitigating neurodegenerative processes.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Meta-Analysis
claimIt should be noted that the present work consists of a review and not a dosing guideline.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognition Meta-Analysis
claim1 1 Brain health is a multidimensional and evolving concept that is difficult to evaluate and quantify [].
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience

Source documents

  1. Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
  2. Natural Molecules for Brain Health and Resilience