Structured evidence table for Isoflavones Skin Hydration Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Isoflavones Skin Hydration Randomized Trial | In exploratory regression analysis limited to S-equol producers, higher urinary S-equol levels were significantly associated with improved under-eye wrinkle parameters and transepidermal water loss (TEWL) at D42. | 2 | Vijayakumar V (2025) | S-equol status modulates skin response to soy isoflavones in postmenopausal women: results from a randomized placebo-controlled pilot trial. |
| Isoflavones Skin Hydration Randomized Trial | Multivariable model adjusting for age, soy intake, phototype and their interactions confirmed that older women experienced greater improvements in undereye wrinkles and barrier function in response to increased S-equol levels. | 2 | Vijayakumar V (2025) | S-equol status modulates skin response to soy isoflavones in postmenopausal women: results from a randomized placebo-controlled pilot trial. |
| Isoflavones Skin Hydration Randomized Trial | Conclusion Soy isoflavone supplementation increased urinary S-equol concentrations and was associated with improvements in under-eye wrinkle appearance, skin hydration, and barrier function-particularly among older postmenopausal women identified as S-equol producers. | 2 | Vijayakumar V (2025) | S-equol status modulates skin response to soy isoflavones in postmenopausal women: results from a randomized placebo-controlled pilot trial. |
| Isoflavones Skin Hydration Randomized Trial | Background/objectives Soy isoflavones may benefit skin health in postmenopausal women, potentially via S-equol, a gut-derived metabolite with enhanced estrogenic and antioxidant activity. | 2 | Vijayakumar V (2025) | S-equol status modulates skin response to soy isoflavones in postmenopausal women: results from a randomized placebo-controlled pilot trial. |
| Isoflavones Skin Hydration Randomized Trial | As a result, isoflavones may promote cell proliferation [], act as antioxidants [], and exert anti-inflammatory and anti-cancer properties [,]. | 2 | Rizzo Julianne (2023) | Soy Protein Containing Isoflavones Improves Facial Signs of Photoaging and Skin Hydration in Postmenopausal Women: Results of a Prospective Randomized Double-Blind Controlled Trial |
| Isoflavones Skin Hydration Randomized Trial | One pilot study showed that the use of an isoflavone-rich soy extract for six months in postmenopausal women significantly increased epithelial thickness, elasticity, collagen fiber quantity, and angiogenesis []. | 2 | Rizzo Julianne (2023) | Soy Protein Containing Isoflavones Improves Facial Signs of Photoaging and Skin Hydration in Postmenopausal Women: Results of a Prospective Randomized Double-Blind Controlled Trial |
| Isoflavones Skin Hydration Randomized Trial | In rats, soy isoflavones significantly increased the thickness of the skin epidermis, collagen fibers in the dermis, and the number of elastic fibers []. | 2 | Rizzo Julianne (2023) | Soy Protein Containing Isoflavones Improves Facial Signs of Photoaging and Skin Hydration in Postmenopausal Women: Results of a Prospective Randomized Double-Blind Controlled Trial |
| Isoflavones Skin Hydration Randomized Trial | 1 2 3 4 5 6 7 8 9 10 11 Plant-derived isoflavones are naturally occurring nonsteroidal compounds that resemble estrogens and are commonly classified as phytoestrogens []. | 2 | Rizzo Julianne (2023) | Soy Protein Containing Isoflavones Improves Facial Signs of Photoaging and Skin Hydration in Postmenopausal Women: Results of a Prospective Randomized Double-Blind Controlled Trial |
Source documents