Structured evidence table for Iron Sleep Quality Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Iron Sleep Quality Randomized Trial | However, the evidence base for TCM pharmacologic interventions in hemodialysis-related RLS remains unclear. | 1 | Zhang J (2026) | Efficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis. |
| Iron Sleep Quality Randomized Trial | Pharmacologic therapy significantly improved IRLS scores (MD -7.84), sleep quality (SMD -0.82), and quality of life (SMD 0.48). | 1 | Zhang J (2026) | Efficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis. |
| Iron Sleep Quality Randomized Trial | A heatmap further revealed that dopaminergic agents were associated with the highest frequency of adverse events, particularly nausea, hypotension, and augmentation. | 1 | Zhang J (2026) | Efficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis. |
| Iron Sleep Quality Randomized Trial | Background Restless Legs Syndrome (RLS) is highly prevalent among adults receiving maintenance hemodialysis and significantly impairs sleep, psychological well-being, and quality of life. | 1 | Zhang J (2026) | Efficacy and safety of pharmacological treatments for restless legs syndrome in hemodialysis patients: a systematic review and meta-analysis. |
| Iron Sleep Quality Randomized Trial | 1 4 5 1 4 5 Recent investigations in this field have improved our mechanistic understanding on RLS, with evidence implicating dopaminergic dysfunction, brain iron deficiency, and additional signaling pathways that may affect sensory symptoms and motor hyperexcitability (,). | 3 | Liu Rujia (2026) | Treatment of restless legs syndrome by acupuncture combined with medicine based on pathophysiological mechanism |
| Iron Sleep Quality Randomized Trial | In addition, research on human genetics has advanced rapidly, with the current largest genome-wide meta-analyses now showing a far larger set of risk loci than previously recognized (including > 100 loci), enabling the identification of significant pathways and risk prediction (). | 3 | Liu Rujia (2026) | Treatment of restless legs syndrome by acupuncture combined with medicine based on pathophysiological mechanism |
| Iron Sleep Quality Randomized Trial | However, despite these findings, knowledge on dopamine biology, iron trafficking and polygenic risk remains not yet fully integrated into a unified, clinically actionable pathophysiological model that may effectively guide individualized therapy across heterogeneous patient subtypes (,,). | 3 | Liu Rujia (2026) | Treatment of restless legs syndrome by acupuncture combined with medicine based on pathophysiological mechanism |
| Iron Sleep Quality Randomized Trial | 1 1 2 3 Restless legs syndrome (RLS; Willis–Ekbom disease) is a common sensorimotor disorder defined by an urge to move the legs but with unpleasant sensations that may worsen at rest, show a circadian pattern (particularly during the evening or at night), and are partially or completely relieved by movement (). | 3 | Liu Rujia (2026) | Treatment of restless legs syndrome by acupuncture combined with medicine based on pathophysiological mechanism |
Source documents