evidence table
Iron Fatigue Meta-Analysis Evidence Table
Structured evidence table for Iron Fatigue Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Iron Fatigue Meta-Analysis | Among high-dose intravenous (IV) iron options, ferric carboxymaltose (FCM) carries a higher risk of treatment-emergent hypophosphatemia than ferric derisomaltose (FDI), with potential clinical consequences. | 3 | Hren R (2026) | The Significance of Hypophosphatemia in Deciding on an Optimal Clinical Choice of Parenteral Iron Therapy in Patients with Chronic Inflammatory Bowel Disease in Slovenia: An Umbrella Review and Economic Evaluation. |
| Iron Fatigue Meta-Analysis | Methods : We integrated two methodological components: (i) a payer-perspective cost-effectiveness analysis using a patient-level microsimulation model with (ii) an umbrella review of systematic reviews and a targeted search of expert consensus statements on IV-iron-associated hypophosphatemia. | 3 | Hren R (2026) | The Significance of Hypophosphatemia in Deciding on an Optimal Clinical Choice of Parenteral Iron Therapy in Patients with Chronic Inflammatory Bowel Disease in Slovenia: An Umbrella Review and Economic Evaluation. |
| Iron Fatigue Meta-Analysis | These findings suggest that hypophosphatemia risk should be considered when selecting IV iron therapy in routine IBD care. | 3 | Hren R (2026) | The Significance of Hypophosphatemia in Deciding on an Optimal Clinical Choice of Parenteral Iron Therapy in Patients with Chronic Inflammatory Bowel Disease in Slovenia: An Umbrella Review and Economic Evaluation. |
| Iron Fatigue Meta-Analysis | Background/Objectives : Iron-deficiency anemia (IDA) is a common extraintestinal complication of inflammatory bowel disease (IBD). | 3 | Hren R (2026) | The Significance of Hypophosphatemia in Deciding on an Optimal Clinical Choice of Parenteral Iron Therapy in Patients with Chronic Inflammatory Bowel Disease in Slovenia: An Umbrella Review and Economic Evaluation. |
| Iron Fatigue Meta-Analysis | In addition, central lesions such as pontine stroke [] or spinal demyelinating plaques [], and peripheral small-fiber neuropathies [], have all been associated with RLS symptoms. | 4 | Ghattas Kyrillos (2026) | Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review |
| Iron Fatigue Meta-Analysis | Nocturnal leg cramps are usually painful, focal, and associated with muscle tightening rather than an urge to move. | 4 | Ghattas Kyrillos (2026) | Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review |
| Iron Fatigue Meta-Analysis | Positional discomfort and arthritis-related pain are also common mimics but are typically localized and not associated with the characteristic relief with movement seen in RLS []. | 4 | Ghattas Kyrillos (2026) | Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review |
| Iron Fatigue Meta-Analysis | 1 2 Restless legs syndrome (RLS) is a common yet often underrecognized neurological disorder marked by an irresistible urge to move the legs, usually accompanied by uncomfortable sensations, such as tingling or crawling, that worsen at rest, intensify in the evening or night, and improve with movement []. | 4 | Ghattas Kyrillos (2026) | Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review |
Source documents