evidence table

Hyaluronic Acid Wrinkle Randomized Trial Evidence Table

Structured evidence table for Hyaluronic Acid Wrinkle Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Hyaluronic Acid Wrinkle Randomized TrialIn accordance with EMA Committee for Advanced Therapies (EMA-CAT) recommendations (Guideline on Human Cell-Based Medicinal Products, 2015, section 2.2.4a), this approach qualifies as a “technique, since the processing does not alter the biological characteristics, physiological functions, or structural properties of the cells.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Acid Wrinkle Randomized Trial20 patients with mild to moderate dermal thinning, reduced elasticity, and wrinkles were assigned to the study group (SG) and treated with Am-FBs (A–C).2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Acid Wrinkle Randomized TrialThe Risk Evaluation and Mitigation Strategies (REMSs) incorporating Elements to Assure Safe Use (ETASU) were applied in Am-FBs and HA-based skin booster treatments, significantly reducing safety-related risks.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Acid Wrinkle Randomized Trial, , , The natural aging process leads to the degradation of the dermal extracellular matrix (ECM), decreased fibroblast activity, and a loss of skin elasticity.Traditional cosmetic procedures, such as hyaluronic acid (HA)-based skin boosters, provide temporary benefits, but autologous cell-based therapies offer a biologically driven regenerative approach.2Gentile Pietro (2026)Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
Hyaluronic Acid Wrinkle Randomized Trial3 4 5 6 During the aging process, the skin undergoes modifications in its structure and function, one of which is reduced hydration in the stratum corneum (), decreased elasticity and firmness due to loss of collagen and hyaluronic acid, and formation of wrinkles and sagging ().2Seto Yosuke (2026)Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial
Hyaluronic Acid Wrinkle Randomized TrialSuch alterations can negatively affect the appearance and self-image, potentially resulting in diminished quality of life (QOL) and reduced social activity ().2Seto Yosuke (2026)Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial
Hyaluronic Acid Wrinkle Randomized TrialIn clinical trial, ingestion of PIC-containing foods was found to be associated with improvements in stratum corneum hydration and skin elasticity (,); however, the specific effects on wrinkle formation—an age-related change that becomes increasingly apparent—remain largely unclarified.2Seto Yosuke (2026)Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial
Hyaluronic Acid Wrinkle Randomized Trial1 2 2 The skin is the largest organ of the body; it not only covers its surface but also serves as a physiological interface between the external environment and the internal environment.2Seto Yosuke (2026)Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial
topicHyaluronic Acid Wrinkle Randomized Trial
claimIn accordance with EMA Committee for Advanced Therapies (EMA-CAT) recommendations (Guideline on Human Cell-Based Medicinal Products, 2015, section 2.2.4a), this approach qualifies as a “technique, since the processing does not alter the biological characteristics, physiological functions, or structural properties of the cells.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Acid Wrinkle Randomized Trial
claim20 patients with mild to moderate dermal thinning, reduced elasticity, and wrinkles were assigned to the study group (SG) and treated with Am-FBs (A–C).
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Acid Wrinkle Randomized Trial
claimThe Risk Evaluation and Mitigation Strategies (REMSs) incorporating Elements to Assure Safe Use (ETASU) were applied in Am-FBs and HA-based skin booster treatments, significantly reducing safety-related risks.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Acid Wrinkle Randomized Trial
claim, , , The natural aging process leads to the degradation of the dermal extracellular matrix (ECM), decreased fibroblast activity, and a loss of skin elasticity.Traditional cosmetic procedures, such as hyaluronic acid (HA)-based skin boosters, provide temporary benefits, but autologous cell-based therapies offer a biologically driven regenerative approach.
evidence level2
citationGentile Pietro (2026)
sourceAutologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
topicHyaluronic Acid Wrinkle Randomized Trial
claim3 4 5 6 During the aging process, the skin undergoes modifications in its structure and function, one of which is reduced hydration in the stratum corneum (), decreased elasticity and firmness due to loss of collagen and hyaluronic acid, and formation of wrinkles and sagging ().
evidence level2
citationSeto Yosuke (2026)
sourceOral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial
topicHyaluronic Acid Wrinkle Randomized Trial
claimSuch alterations can negatively affect the appearance and self-image, potentially resulting in diminished quality of life (QOL) and reduced social activity ().
evidence level2
citationSeto Yosuke (2026)
sourceOral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial
topicHyaluronic Acid Wrinkle Randomized Trial
claimIn clinical trial, ingestion of PIC-containing foods was found to be associated with improvements in stratum corneum hydration and skin elasticity (,); however, the specific effects on wrinkle formation—an age-related change that becomes increasingly apparent—remain largely unclarified.
evidence level2
citationSeto Yosuke (2026)
sourceOral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial
topicHyaluronic Acid Wrinkle Randomized Trial
claim1 2 2 The skin is the largest organ of the body; it not only covers its surface but also serves as a physiological interface between the external environment and the internal environment.
evidence level2
citationSeto Yosuke (2026)
sourceOral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial

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Source documents

  1. Autologous fibroblast therapy for facial rejuvenation: A randomized open-label controlled study
  2. Oral supplementation with piceatannol improves skin hydration and reduces wrinkle severity: a randomized, double-blind, placebo-controlled trial